Established for forty years as the definitive reference on lupus, Dubois' Lupus Erythematosus is now in its thoroughly revised, updated Seventh Edition.

Dubois' Lupus Erythematosus provides comprehensive coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education.

This edition focuses on evidence-based findings, treatment consensuses, and practical clinical information. New chapters cover cytokines and interferons, pathogenesis of atherosclerosis, immune tolerance, clinical indices in assessment of lupus, mixed connective tissue disease, reproductive issues, fibromyalgia, gender-related issues, and biomarkers.

Contents

History and Definitions

1. Historical Background of Discoid and Systemic Lupus Erythematosus
2. Definition and Classification of Systemic Lupus Erythematosus
3. Environmental Aspects of Lupus
4. Epidemiology of Systemic Lupus Erythematosus

Pathogenesis

5. Pathogenesis of Systemic Lupus Erythematosus
6. Genetics of Human Lupus
7. Genetics of Murine Systemic Lupus Erythematosus
8. Apoptosis
9. Interaction of T Cells with Cells of the Innate Immune System and B Cells in the Pathogenesis of SLE
10. Cytokines and Interferons in Lupus
11. B Cells in Systemic Lupus Erythematosus
12. Abnormalities in Immune Complex Clearance and Fcγ Receptor Function
13. Complement and Systemic Lupus Erythematosus
14. Mechanisms of Acute Inflammation and Vascular Injury in Systemic Lupus Erythematosus
15. Idiotypes and Idiotype Networks
16. The Importance of Sex Hormones in Systemic Lupus Erythematosus
17. Neuroendocrine Immune Interactions: Principles and Relevance to Systemic Lupus Erythematosus
18. Animal Models of Systemic Lupus Erythematosus
19. Pathogenesis of Atherosclerosis in Lupus
20. Autoantigens and Defects in Immune Tolerance in Lupus

Autoantibodies

21. Structure and Derivation of Antibodies and Autoantibodies
22. Antinuclear Antibodies: An Overview
23. Antibodies to DNA
24. Antibodies to Histones and Nucleosome-Related Antigens
25. Antibodies to Ro/SSA and La/SSB
26. Antibodies to Spliceosomal Components
27. The Lupus Anticoagulant and Antiphospholipid Antibodies
28. Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus

The Skin in Lupus

29. Pathomechanisms of Cutaneous Lupus Erythematosus
30. Lupus-Specific Skin Disease (Cutaneous LE)
31. Lupus-Nonspecific Skin Disease

Clinical Aspects of Lupus

32. Clinical Presentation of Systemic Lupus Erythematosus
33. The Musculoskeletal System
34. Cardiovascular Manifestations of Lupus
35. Pulmonary Manifestations of Systemic Lupus Erythematosus
36. Clinical Aspects of Vasculitis and Selected Cutaneovascular Manifestations of Systemic Lupus Erythematosus
37. The Nervous System
38. Psychopathology of Lupus and Neuroimaging
39. Head & Neck Findings in Systemic Lupus Erythematosus: Manifestations Involving the Eye, Ear and Larynx
40. Ocular, Aural & Oral Manifestations
41. Hematologic & Lymphoid Abnormalities in Systemic Lupus Erythematosus
42. Gastrointestinal and Hepatic Manifestations
43. Systemic Lupus Erythematosus in Childhood & Adolescence
44. Drug-Induced Lupus
45. Infections in Systemic Lupus Erythematosus
46. Serum and Plasma Protein Abnormalities and Other Clinical Laboratory Determinations in Systemic Lupus Erythematosus
47. Clinical Indices in the Assessment of Lupus
48. Clinical Application of Serologic Abnormalities in Systemic Lupus Erythematosus
49. Differential Diagnosis and Disease Associations
50. Mixed Connective Tissue Disease and Overlap Syndromes
51. The Mother in Systemic Lupus Erythematosus
52. The Fetus in Systemic Lupus Erythematosus
53. Neonatal Lupus
54. Reproductive Issues in Women with Autoimmune Disease
55. Lupus Nephritis: Pathology & Pathogenesis
56. Clinical and Laboratory Features of Lupus Nephritis

Management of Lupus

57. Principles of Therapy and Local Measures
58. Nonsteroidals and Salicylates for Systemic Lupus Erythematosus
59. Antimalarial Therapies
60. Systemic Glucocorticoid Therapy in Systemic Lupus Erythematosus
61. Immunosuppressive Drug Therapy
62. Nonpharmacologic and Complementary Therapeutic Modalities
63. Fibromyalgia in SLE and Use of Complementary and Alternative Medicine in SLE
64. Hormones and Gender-Related Issues
65. Clinical and Management Aspects of the Antiphospholipid Antibody Syndrome
66. Additional Therapies Used in the Management of Lupus
67. Adjunctive Measures and Issues: Allergies, Antibiotics, Vaccines and Disability
68. Issues in Drug Development in SLE: Clinical Trial Design, Outcome Measures and Biomarkers
69. Prognosis, Mortality and Morbidity in Systemic Lupus Erythematosus
70. Biologics and Stem Cell Therapies for Lupus

Appendices

• A Patient's Guide to Lupus Erythematosus
• Lupus Resources
• The Medical Outcome Survey Short-Form General Health Survey

Index

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