edited by Hemin R. Chin
and Steven O. Moldin

• Discusses state-of-the-art methods used to characterize the genetic basis of the nervous system and complex behavior

• Presents clearly written chapters, making each methodology accessible to neuroscientists with different levels of experience and expertise in molecular techniques

• Provides researchers with detailed information for choosing and implementing the appropriate genetic methodology for their application

Methods in Genomic Neuroscience provides newcomers and experienced researchers with a reference guide for applying powerful, state-of-the-art molecular genetic techniques to the study of neural and behavioral systems. It thereby provides a foundation by which data on gene expression and function may be used to develop new therapeutic strategies for brain diseases.

Authored by researchers in the forefront of genomic neuroscience, the book addresses state-of-the-art tools and technologies for global analysis of genes influencing the nervous system and its disorders. An emphasis is placed on massively parallel approaches for analyzing the avalanche of data that is being generated from the full genomic sequence of humans and model systems.

Specific topics include human sequence variation, methods for discovering disease vulnerability genes, gene-environmental interaction, gene expression analysis using DNA microarrays, random mutagenesis, gene trap approaches for studying brain development, neural stem cells, gene targeting, and gene delivery.

Contents

1. Gene-Environment Interaction and Complex Behavior
2. Current Perspectives on the Genetic Analysis of Naturally-Occurring Neurological Mutations in Mice
3. Conditional and Inducible Gene Targeting in the Nervous System
4. Functional Identification of Neural Genes
5. Studying Brain Development and Wiring Using a Modified Gene Trap Approach
6. N-Ethyl-N-Nitrosourea (ENU) Mutagenesis: Functional Analysis of the Mouse Nervous System and Behavior
7. DNA Arrays and Gene Expression Analysis in the Brain
8. DNA Microarrays and Human Brain Disorders
9. Full-Length cDNA Libraries: Reagents for Functional Studies of the Nervous System
10. Methods for Gene Delivery to Neural Tissue
11. Neural Stem Cells and Brain Repair
12. Statistical Methods to Discover Susceptibility Genes for Nervous System Diseases
13. Genetic Variation Analysis of Neuropsychiatric Traits

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