Mircoorganisms and Bioterrorism has the most up-to-date information concerning microbes with potential as bioterrorist weapons.

Mircoorganisms and Bioterrorism primary audience includes:

• microbiologists
• bacteriologists
• virologists
• mycologists

Contents

1. Biotechnology and the Public Health Response to Bioterrorism

• US Public Health Service Infrastructure-the Laboratory Response Network
• Detection, Monitoring, and Identification of BT Agents
• The Potential for Misuse of Biotechnology
• Biotechnology, Public Health Interest and the Exchange of Scientific Information

2. Historical Perspectives of Mircobial Bioterrorism

• Early use of Biological Agents in Warfare
• The Germ Theory and Bioterrorism
• Concluding Remarks and Perspectives

3. The Infectious Disease Physician and Microbial Bioterrorism

• The Evolution of the Global Community, Infection, and Bioterrorism
• The Evolving Practice of Infectious Disease Physician with Public Health Response
• Prevention, Early Recognition, and the Infectious Disease Physician
• Education, the Infectious Disease Physician, and Preparedness

4. Modulation of Innate Immunity to Protect Against Biological Weapon Threat

• Bioterrorism and Biological Weapons Threat
• Immune System
• Innate Immunity
• Pulmonary Innate Immunity
• Modulation of Immunity for Protection Against Infection
• Modulation of Innate Immunity to Protect Against Biological Weapon Threat- a Summary

5. Smallpox: Pathogenesis and Host Immune Responses Relevant to Vaccine and Therapeutic Strategies

• History of Smallpox Infection and its Eradication
• Clinical and Epidemiological Features
• Virus Structure and Classification
• Pathogenesis, Host Defense, and the Immune Response
• Features of Smallpox Making it a Likely Bioterror Agent
• History and Potential of Smallpox as a Bioweapon
• Smallpox Vaccines and Antiviral Therapies

6. Bacillus Anthracis: Agent of Bioterror and Disease

• Clinical Presentation of Anthrax
• B. Anthracis and Bioterror
• Evolution into a Pathogen
• Spore Structure and Function
• Virulence Factors
• B. Anthracis and Macrophage Interactions
• Vaccine and Therapeutic Approaches

7. Tularemia Pathogenesis and Immunity

• Pathogenesis
• Immunity

8. Brucella and Bioterrorism

• Brucellosis: a Zoonotic Disease
• Clinical Symptoms of Human Brucellosis
• Life Within the Macrophage and Subversion of Host Immune Responses
• History of the Use of Brucella as an Agent of Biological Warfare
• Impact of an Attack Using Brucella as an Agent of Bioterrorism
• Diagnosis and Treatment of Brucellosis
• Vaccine Development: Historical Perspectives and Considerations for the Future

9. Pneumonic Plague

• Plague in Humans
• Bacterial Pathogenesis
• Bacterial Genetics
• Epidemiology of Pneumonic Plague
• Current and Future Needs

10. Coxiella Burnetii, Q Fever, and Bioterrorism

• A Brief History
• Q Fever
• Epidemiology
• Coxiella Burnetii Lifecycle Stages
• Coxiella Burnetii Genome
• Lipopolysaccharide
• Phase Transition
• Invasion of Host Cells
• Environment of Acidified Phagosome
• Metabolic Pathways
• Transport
• Transformation Studies
• Coxiella Burnetii Outbreaks in the Military
• Coxiella Burnetii as a Biological Weapon
• Sterilization/ Disinfection
• Detection Methods
• Treatments of Q Fever
• Vaccine

11. Genomic and Proteomic Approaches Against Q Fever

• Disease and Threat
• Host-Parasite Interaction
• Secretion of Virulence Factors
• Pathogenesis
• Isolated Diversity and Virulence
• Acquired Immunity
• Whole Cell C. Burnetii Vaccines
• New Opportunities with Genomic and Proteomic Approaches

12. Rickettsia Rickettsii and Other Members of the Spotted Fever Group as Potential Bioweapons

• SFG Rickettsiae with Bioweapon Potential
• Feasibility of Obtaining, Propagating, Stablizing, and Weaponizing SFG Rickettsiae
• Methods of Dispersal
• Pathogenesis of Aerosol Transmission
• Available Methods for Diagnosis, Treatment, and Prevention
• Needed Countermeasures

Index

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