Microfluidic Lab-On-A-Chip for Chemical and Biological Analysis and Discovery allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated.

Features:

• Reviews basic principles of micromachining and fluid flow and control for lab-on-a-chip technology
• Emphasizes analytical applications of microfluidic technology
• Includes information key to cell, nucleic acid, protein, and genetic analyses, including DNA sequencing
• Adapts traditional principles of operations for the size of a chip, optimizing the miniaturization advantage and favorable scaling down
• Gleans significant and detailed references from the vast literature on each topic for the more experienced researcher
• Contains figures that represent novel designs and breakthroughs in the field, tables that summarize related materials, and problem sets that test comprehension of the material

Contents

• Micromachining Methods
• Micromachining of Silicon
• Micromachining of Glass
• Micromachining of Fused Quartz (or Fused Silica)
• Micromachining of Polymeric Chips
• Metal Patterning
• World-to-Chip Interface
• Microfluidic Flow
• Liquid Pumping Methods
• Microfluidic Flow Control
• Sample Introduction
• Electrokinetic Injection
• Hydrodynamic Injection
• Other Sample Injection Methods
• Sample Pre-concentration
• Sample Stacking
• Extraction
• Porous Membrane
• Other Pre-concentration Methods
• Separation
• Gas Chromatography (GC)
• Capillary Electrophoresis (CE)
• Chromatographic Separations
• Coupled Separations
• Detection Methods
• Optical Detection Methods
• Electrochemical (EC) Detection
• Mass Spectrometry (MS)
• Other Detection Methods
• Applications to Cellular/Particle Analysis
• Retention of Cells and Particles
• Studies of Cells in a Flow
• Other Cell Operations
• Applications to Nucleic Acids Analysis
• Nucleic Acids Extraction and Purification
• Nucleic Acids Amplification
• DNA Hybridization
• Other Nucleic Acid Applications
• Applications to Protein Analysis
• Immunoassay
• Protein Separation
• Enzymatic Assays

Index

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