Molecular Mechanisms of Fanconi Anemia will give research students a platform for further investigation, and act as a source of information regarding experimental design.

Molecular Mechanisms of Fanconi Anemia is useful for its comprehensive description of Fanconi Anemia and information on the latest molecular theories underlying its causes.

Contents

1. Clinical Features of Fanconi Anaemia

• Genetics of Fanconi Anaemia
• Clinical Features of Fanconi Anaemia
• Fanconi Anaemia and Nijmegen Breakage Syndrome
• Confirmation of the Diagnosis in FA Patients
• Relationship of Complementation Group to Clinical Features
• Evidence for Modifying Mutations

2. The Genetics Basis of Fanconi Anemia

• Genetic Heterogeneity
• The FANC Genes
• FA Protein Complexes

3. The FANCA Gene and Its Products

• FANCA Gene
• FANCA Protein
• FANCA Function
• Acquired AML and FANCA Defects

4. The FANCC Gene and Its Products

• Clining and Characeristics of the FANCC Gene
• Mammalian Homologs of FANCC
• FANCC Gene Mutations
• Expression of the FANCC Gene Products
• FANCC Protein Expression and Stability
• FANCC Subcellular Localization
• FANCC in the Cellular Response to ICL Inducers
• Apoptosis
• FANCC Loss of Function
• FANCC and Cytokine Signalling
• FANCC and Oxidative Stress

5. The FANC B, F and G Genes and Their Products

• FANCB
• FANCG
• FANCF
• FANCE

6. FANCD1/BRCA2 and FANCD2

• The FA-D Complementation Group

7. The FANC Genome Surveillance Complex

• Historial Overview
• Structure of the FA Core Complex
• Functions of th FA Core Complex
• Perspectives

8. Other Proteins and Their Interactions with FA Gene Products

• FANCC-Binding Proteins
• FANCA0-Binding Proteins
• FA Protein Complex and Human α Spectrin II

9. Fanconi Anaemia and Oxidative Stress: Cellular and Clinical Phenotypes

10. Therapy for Fanconi Anemia

• Androgens
• Hematopoietic Growth Factors
• BM Transplants
• Gene Therapy
• Prospects for Therapy

11. Mutational Analyses of Fanconi Anemia Genes in Japanese Patients

• Patients, Cell Culture and Mutation Analysis
• Sequence Variations in the FANCA Gene
• Sequence Variations in the FANCG Gene
• Mutations of the FANCC Gene
• Mutations of Other FA Genes
• Characteristics and Genetic Basis of Japanese FA Patients

Index

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ORDER NOW Molecular Mechanisms of Fanconi Anemia by Shamim I. Ahmad 2006 • 121 pages • $138.00 + shipping Texas residents please add 6.75% sales tax