Intended for basic scientists, toxicologists, chemists, regulators, risk assessors, and others involved in assessing the safety of manufactured nanomaterials, Nanotoxicology: Characterization, Dosing and Health Effects:

• discusses nanotoxicology techniques, dosing regimens, agglomeration problems, pharmacokinetics, and exposure assessments
• provides information on screening methods to assess nanomaterials, as well as proteomic screening and gene expression profiling
• includes nomenclature standards, preparations, characterization, and obstacles in in-vitro and in-vivo studies
• describes nanotoxicity in specific organs, including lung, skin, cardiovascular, and nervous system
• features a section on the effects of nanomaterials on ecological systems and bioremediation methods

Contents

1. Nanotoxicology:Laying a firm Foundation for Sustainable Nanotechnologies
2. Carbon Nanotube Structures and Compositions: Implications for Toxicological Studies
3. Effect-Oriented Physico-chemical Characterization Methods of Nanomaterials
4. Physico-chemical Characteristics of Nanoparticles which Determine their Potential Toxicity
5. Exposure Assessment for Safe Nanotechnology
6. Biodistribution of Nanoparticles: Insights from Drug Delivery
7. Nanoparticle Interactions with Biological Membranes: A Proposed Physical Mechanism
8. Placental Biological Barrier Models for Evaluation of Nanoparticle Transfer
9. Pharmacokinetics of Nanomaterials
10. Estimating Nanoparticle Dose in Humans: Issues and Challenges
11. Dispersion of Nanoparticles in Pulmonary Surfactants for In Vitro Toxicity Studies: Lessons from Ultrafine Diesel Exhaust Particles and Fine Mineral Dusts
12. Gene-Cellular Interactions of Nanomaterials: Genotoxicity to Genomics
13. Effect of Carbon Nanotube Exposure on Keratinocyte Protein Expression
14. Critical Issues in the Evaluation of Possible Adverse Pulmonary Effects Resulting from Airborne Nanoparticles
15. Carbon Nanotube Exposure and a Risk for Cardiovascular Effects
16. Hemostatic and Thrombotic Effects of Particulate Exposure: Assessing the Mechanisms
17. Pulmonary and Cardiovascular Effects of Nanoparticles
18. Understanding the Potential Neurotoxicology of Nanoparticles
19. Dermal Effects of Nanomaterials
20. Toxicity of Nanoparticles in the Eye
21. Nanoparticle Interactions with Biological Systems and Subsequent Activation of Intracellular Signaling Mechanisms
22. Occurrences, Fate and Characterization of Nanoparticles in the Environment
23. Impact of Nanoparticles on Aquatic Organisms
24. The Environmental Implications of Nanomaterials
25. Nanotechnology and Toxicology: How Do We Move Forward?

Index

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