Nasal Systemic
Drug Delivery
by Yie W. Chen, Kenneth Su and Shyi-Feu Chang

Providing a comprehensive treatment of the topic, Nasal Systemic Drug Delivery furnishes, in one volume, an extensive literature review of all available scientific material and presents the authors' recent laboratory investigations.

A critical assessment of this growing field of biomedical research, the book:

• Describes nasal anatorhy and physiology

• Discusses animal models used for in vivo and ex vivo nasal absorption studies

• Considers physicochemical, biopharmaceutical, and toxicophysiological features of nasal drug delivery

• Covers the intranasal delivery of peptide/protein and diagnostic drugs, and nonpeptide molecules

• And much more!

Contents

1. Anatomy and Physiology of the Nose
   • Nasal Passage
   • Nasal Epithelium
   • Nasal Secretions
   • Nasal Mucociliary Clearance
   • Nasal Blood Flow
   • Nasal Nerve Supply
   • Nasal Enzymes
   • Nasal pH
   • Nasal Olfactory Region
   • Nasal Pathophysiology

2. Animal Models Used in Nasal Absorption Studies
   • In Vivo Nasal Absorption Models
   • Ex Vivo Nasal Perfusion Model

3. Physicochemical, Biopharmaceutical, and Toxicophysiological Considerations
   • Physicochemical Properties of Drugs
   • Parameters Affecting Nasal Absorption
   • Pathways for Nasal Absorption
   • Enhancement of Nasal Drug Absorption
   • Drug Distribution in the Nasal Cavity
   • Delivery Systems for Intranasal Drug Administration
   • Drug Deposition in the Nasal Cavity
   • Pharmacokinetics of Nasal Absorption
   • Nasal Irritation Assessment
   • Toxicological Evaluations

4. Intranasal Delivery of Peptide/Protein Drugs
   • Amino Acids
   • Peptides
   • Polypeptides and Proteins
   • Other Therapeutically Important Biological Products

5. Intranasal Delivery of Nonpeptide Molecules
   • Adrenal Corticosteroids
   • Sex Hormones
   • Vitamins
   • Cardiovascular Drugs
   • Autonomic Nervous System Drugs
   • Central Nervous System Stimulants
   • Narcotics and Antagonists
   • Histamines and Antihistamines
   • Antimigraine Drugs
   • Antibiotics
   • Antiviral Agents
   • Inorganic Compounds

6. Intranasal Delivery of Diagnostic Drugs
   • Phenolsulfonphthalein
   • Dye T-1824
   • Vital Dyes
   • Potassium Ferrocyanide
   • Secretin
   • Pentagastrin
   • Cerulein

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