Written by experts at the forefront of current research and clinical practice, this volume provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents.

Coverage includes:

• Specific recommendations for all major drug classes and diseases
• A detailed section on drugs and the newborn
• Chapters on specific treatment settings such as the pediatric intensive care unit and emergency room
• Plus much more!

Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, drug development, and clinical drug trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.

Contents

1. General Principles
   1. Introduction and Historical Perspectives
   2. Clinical Pharmacokinetics in Infants and Children
   3. Drug Action and Therapy in the Infant and Child
   4. Drug Metabolism and Disposition in Infants and Children
   5. Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics
   6. Compliance with Pediatric Medication Regimens
   7. Clinical Trials Involving Children: History, Rationale, Regulatory Framework and Technical Considerations
   8. Ethics of Drug Research in Pediatric Populations
   9. Therapeutic Drug Monitoring
   10. Drug Formulations

2. Drugs and the Newborn
   11. Developmental Toxicology
   12. Placental Transfer of Drugs
   13. Principles of Neonatal Pharmacology
   14. Perinatal Origins of Adult Defects in Drug Metabolism
   15. Renal Function and Excretion of Drugs in the Newborn
   16. The Excretion of Drugs and Chemicals in Human Milk
   17. Drugs for Hyperbilirubinemia
   18. Drugs and Lung Development
   19. Pharmacologic Treatment of Neonatal Apnea
   20. Drugs and Perinatal Brain Injury
   21. Antiretroviral Pharmacology in Pregnant Women and Newborns

3. Drugs in Special Populations and Settings
   22. Therapeutic Applications in Pediatric Intensive Care
   23. Drug Therapy in the Pediatric Emergency Department
   24. Drug Therapy in the Adolescent
   25. Topical Medications
   26. Ophthalmologic Drugs in Infants and Children

4. Specific Drugs
   27. Sulfonamides
   28. Penicillins, Beta-Lactamase Inhibitors, Cephalopsporins and Other Beta-Lactams
   29. Aminoglycosides and Glycopeptides
   30. Macrolides, Chloramphenicol, and Tetracyclines
   31. Anthelminthic Drugs in Children
   32. Antituberculosis Drugs
   33. Antifungal Agents
   34. Antiviral Drugs
   35. Anticonvulsants
   36. Psychopharamacology in Children and Adolescents
   37. Antihistamines
   38. Antiasthmatics
   39. Antipyretics
   40. Cardiovascular Drugs
   41. Diuretics
   42. Clinical Pharmacology of Antineoplastic Drugs
   43. Immunosuppressive and Immunomodulatory Drugs
   44. Analgesic Agents
   45. Local Anesthetics for Infants and Children
   46. Nonsteroidal Antiinflammatory Drugs
   47. Antihypertensive Agents
   48. Gastrointestinal Drugs
   49. Glucocorticoids
   50. Insulin and Diabetes Mellitus
   51. Thyroid Hormones
   52. Growth Hormone
   53. Hematologic Agents
   54. Nutrient Supplements
   55. Childhood Vaccines

5. Adverse Drug Effects and Interactions
   56. Epidemiology of Adverse Drug Effects
   57. Medication Errors
   58. Pediatric Poisonings and Antidotes
   59. Use of Herbal Products in Children: Risks and Unproven Benefits
   60. Neonatal Abstinence Syndromes

Appendices
Index

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