New Treatment Strategies For Dengue and Other Flaviviral Diseases features contributions from the world’s leading researchers working on dengue and related flaviviruses who examine the current state of the art in the molecular biology of the dengue virus.

Dengue virus is a member of the Flaviviridae family, which includes viruses associated with human diseases such as yellow fever, Japanese encephalitis and hepatitis C. Dengue fever is transmitted by mosquitoes, principally Aedes aegypti.

Contents

1. Dengue/dengue hemorrhagic fever: history and current status
2. Molecular biology of flaviviruses
3. Development of novel antivirals against flaviviruses
4. Entry functions and antigenic structure of flavivirus envelope proteins
5. Multiple enzyme activities of flavivirus proteins
6. Towards the design of flavivirus helicase/NTPase inhibitors: crystallographic and mutagenesis studies of the dengue virus NS3 helicase catalytic domain
7. Finding new medicines for flaviviral targets
8. Structural and functional analysis of dengue virus RNA
9. Organization of flaviviral replicase proteins in virus induced membranes: a role for NS1’ in Japanese encephalitis virus RNA synthesis
10. CRM1 dependent nuclear export of dengue virus type-2 NS5
11. T cell responses and dengue haemorrhagic fever
12. The evolutionary biology of dengue virus
13. Developing vaccines against flavivirus diseases: past success, present hopes and future challenges
14. A genomics approach to understanding host response during dengue infection
15. Mouse and hamsters models rodent models for the study of therapy against flavivirus infections
16. Secretion of flaviviral non-structural protein NS1: from diagnosis to pathogenesis

Index

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