edited by
Stefan H.E. Kaufmann

Novel Vaccination Strategies offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology.

It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Contents

1. Preface
   1. Introduction: Challenges for the vaccine developer, including correlates of protection

2. Vaccination and Immune Response
   2. Shaping adaptive immunity against pathogens: the contribution of innate immune responses
   3. Adjuvant-induced Th2- and Th1-dominated immune responses in vaccination
   4. Memory
   5. T cell-based vaccines

3. Adjuvants
   6. Microbial adjuvants
   7. Host-derived adjuvants
   8. Microparticles as vaccine adjuvants and delivery systems
   9. Liposomes and ISCOMs
   10. Virosomal technology and mucosal adjuvants

4. Classical and Novel Vaccination Strategies: A Comparison
   11. Classical bacterial vaccines
   12. Subunit vaccines and toxoids
   13. Engineering virus vectors for subunit vaccines
   14. Update on antiviral DNA vaccine research (2000-2003)
   15. Live recombinant bacterial vaccines
   16. Mucosal vaccination
   17. Passive vaccination and antidotes: A novel strategy for generation of wide-spectrum protective antibodies
   18. Plant-based oral vaccines
   19. Virus-like particles: Combining innate and adaptive immunity for effective vaccination

5. Vaccines for Specific Targets
   20. Helicobacter pylori
   21. Novel vaccination strategies against tuberculosis
   22. Rationale for malaria vaccine development
   23. Vaccine for Specific Targets: HIV
   24. Vaccines against bioterror agents

6. Vaccines in the Real World: Safety, Cost Efficiency and Impact of Vaccination
   25. Imperfect vaccines and the evolution of pathogen virulence
   26. Cost-effectiveness of vaccinations
   27. Immunological safety of vaccines: facts, hypothesis and allegations

Index

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