Oncogenomics: Molecular Approaches to Cancer offers the first rigorous yet broadly accessible treatment of the impact of genomics on cancer research and care. Clearly written by world-renowned scientists in the field, and edited for overall cohesion, this book progresses logically from molecular profiling to model systems, cancer pharmacology, and clinical trials.

Features:

• Covers cutting-edge issues such as array-based diagnostics, pharmaco-genomics, and molecularly targeted therapeutics
• Includes discussions of ethical, legal, and social issues related to cancer genomics and clinical trials
• Provides links to online oncogenomic resources and references

Recognizing the multidisciplinary character of Oncogenomics, the editors include an advanced introduction to cancer genetics and cancer pharmacology that makes accessible state-of-the-art topics such as expression profiling, SNPs in cancer, tissue microarrays, and chemical and genetic validation studies. Scientists, oncologists, and other healthcare professionals, as well as advanced students, will find this reference an essential resource for elucidating this exciting field.

Contents

1. Introduction
   1. At the Precarious Cusp of Oncogenomics

2. Molecular Profiling in Cancer: DNA, RNA and Protein
   2. Genome-Wide Searches for Mutations in Human Cancer
   3. Molecular Cytogenetics: Increasing Resolution Using Array-Based CGH
   4. SNPs and Functional Polymorphisms in Cancer
   5. Expression Profiling of Breast Cancer: From Molecular Portraits to Clinical Utility
   6. Classifying Hereditary Cancers and Phenocopies of Hereditary Cancers Using Expression Arrays
   7. Linking Drugs and Genes: Pharmacogenomics, Pharmacoproteomics, Bioinformatics, and the NCI-60
   8. Tissue Microanalysis: Profiling Cancer Stages
   9. Proteomic s in Bladder Cancer

3. Model Systems
   10. Chemical and Genetic Methods to Validate Targets in Nonmammalian Organisms
   11. Mouse Models of Cancer
   12. Genome-Wide Modifier Screens: How the Genetics of Cancer Penetrance May Shape the Future of Prevention and Treatment

4. Molecularly Targeted Drugs
   13. Protein Kinases as Targets in Cancer Therapy: Validated and Emerging Approaches
   14. Ras Superfamily-Directed Compounds
   15. Clinomics: Post-Genomic Cancer Care

5. Conclusion
   16. Oncogenomics and the NCI Director’s Vision for 2015

Index

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