Ophthalmic Drug Delivery Systems presents new and comprehensive chapters on anterior and posterior segment microdialysis, ocular drug delivery, and ophthalmic formulation design.

It examines the lates strategies in gene therapy, ocular microdialysis, vitreous drug disposition modeling, and receptor/transporter targeted drug delivery.

Contents

Fundamental Considerations

• Overview of Ocular Drug Delivery
• Membrane Transport Processes in the Eye
• General Considerations in Ocular Drug Disposition

Transport Models in Ocular Drug Delivery

• Ocular Drug Transfer Following Systemic Drug Administration
• Ocular Pharmacokinetics and Pharmacodynamics
• Mathematical Modeling of Drug Distribution in th Vitreous Humour
• Anterior Segment Microdialysis
• Posterior Segment Microdialysis

Drug Delivery Systems

Part A: Conventional Systems

• Ocular Penetration Enhancers
• Corneal Collagen Shields for ocular Delivery
• The Non-Corneal Route in Ocular Drug Delivery
• Ocular Iontophoresis
• Mucoadhesive Polymers in Ophthalmic Drug Delivery
• Microparticulates and Nanoparticles in Ocular Drug Delivery
• Dendrimers: An Innovative and Enhanced Ocular Drug Delivery System

Part B: Delivery of Macromolecular Therapeutic Agents

• Ocular Delivery and Therapeutics of Peptides and Proteins
• Retinal Disease Models for Development of Drug and Gene Therapies
• New Experimental Therapeutic Approaches for Degenerative Diseases of the Retina
• Gene Oligonecleotide and Ribozyme Therapy in the Eye

Regulatory Aspects

• Regulatory Considerations
• Patent Considerations

Index

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