edited by Albert Lauwers
and Simon Scharpe

This well-integrated, one-of-a-kind resource offers comprehensive, interdisciplinary analyses of the entire pharmaceutical enzyme field—from molecular biology to clinical pharmacology. Highlights practical, previously unpublished information, immediately useful in industry and academic institutions!

Emphasizing pharmacology and clinical impact, Pharmaceutical Enzymes:

• discusses robust methods of measurement and evaluation
• reviews current knowledge on the bioavailability of pharmaceutical enzymes
• presents different chemical approaches to tailoring enzymes for the improvement of therapeutic effectiveness
• provides a step-by-step approach to molecular modeling
• describes recently introduced pharmaceutical products, including glucocerebrosidase for the treatment of Gaucher’s disease and deoxyribonuclease for cystic fibrosis
• furnishes unique laboratory guidelines for the testing and quality control of pharmaceutical enzymes
• and more!

With over 1200 bibliographic citations, figures, and tables, Pharmaceutical Enzymes is an indispensable, day-to-day reference for pharmacologists, enzymologists, microbiologists, organic and medicinal chemists and biochemists, biophysicists, biotechnologists, molecular and membrane biologists, immunologists, physiologists, pharmaceutical development managers, regulatory affairs personnel, and graduate-level students in these disciplines.

Contents

1. Bioavailability of Pharmaceutical Enzymes
   • Biopharmaceutical Aspects of Enzyme Absorption
   • The Endothelium Monolayer: Barrier to Enzyme and Drug Delivery

2. Tailoring of Pharmaceutical Enzymes
   • Enzyme-Albumin Conjugates: Advantages and Problems with Targeting
   • Acyl Enzymes as Prodrugs
   • Molecular Modeling of Pharmaceutical Important Targets

3. Biochemical and Pharmacological Properties
   • Cystein Proteinases from the Latez Carica papya L.
   • Bromelein
   • Hyaluronidase
   • Exocrine Pancreas Substitution
   • I-Asparagnase - An Essential Antineoplastic Drug
   • Macrophage-Targeted Glucocerebrosidase: A Therapeutically Effective Enzyme Replacement Product for Gaucher Disease
   • Desoxyribonuclease
   • Therapeutic Protein Inhibitors of Elastase

4. Standardization and Methodology
   • Good Standardization Practices
   • Assays

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