Pharmaceutical
Skin Penetration Enhancement

edited by Kenneth A. Walters
and Jonathan Hadgraft

This reference fills the void in the highly specialized field of pharmaceutical penetration enhancement in human skin. It blends theory and practice in one volume that proves to be useful as a textbook as well as a reference

Pharmaceutical Skin Penetration Enhancement is an excellent addition to the library of scientists working in the field of drug or chemical penetration into and through the skin.

Contents

1. Water: The Most Natural Penetration Enhancer
2. Simple Alkyl Esters as Skin Penetration Enhancers
3. Phosopholipids as Skin Penetration Enhancers
4. Terpenes as Skin Penetration Enhancers
5. Mechanisms and Prediction of Nonionic Surfactant Effects on Skin Permeability
6. Interaction Between Anionic Surfactants and Skin
7. Azone: Mechanisms of Action and Clinical Effect
8. In Vitro Analysis of QSAR in Wanted and Unwanted Effects of Azacycloheptanonesas Transdermal Penetration Enhancers
9. Oleyl Surfactants as Skin Penetration Enhancers: Skin Irritation and In Vitro Toxicity to Cultured Human Skin Cells
10. Synergistic Effects in Percutaneous Enhancement
11. Supersaturated Solutions as Topical Drug Delivery Systems
12. Infrared Spectroscopy of Stratum Corneum Lipids: In Vitro Results and Their Relevance to Permeability
13. The Use of Ultrasound in Skin Penetration Enhancement
14. Iontophoretic Drug Delivery
15. Technological Aspects of Penetration Enhancers in Transdermal Systems
16. Veterinary Applications of Skin Penetration Enhancers
17. Hydrotropy and Penetration Enhancement
18. Molecular Modeling of Skin Permeation Enhancement by Chemical Agents
19. Skin Penetration Enhancement: Clinical Pharmacological and Regulatory Considerations

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