edited by
Raphael M. Ottenbrite
and Sung Wan Kim

Includes information on:

• New developments in bioactive polymers for pharmaceutical and biomaterials applications
• Polymers as drugs, prodrugs, drug delivery systems, and in situ prostheses
• New materials for degradation for controlled drug release
• Synthesis, derivatization, characterization, applications, and evaluation techniques
• Biodegradable materials, assemblies, hydrogels, telechelic polymers, derivatized polysaccharides, micro- and nanoparticles, mimetic protein networks, and interpenetrating polymers
• Antimicrobial treatment using polymer systems
• Discussions of improved and enhanced material properties for medicinal applications
• Over 150 table and figures

Polymeric Drugs and Drug Delivery Systems publishes consists of twenty-two recent research-based reports reports on the developments in these areas of pharmaceutical and biomaterials technology. The reports were prepared by top scientists in the field and are based on current research conducted at leading laboratoriesresearch organizations in the U.S.A., Europe, and Far EastAsia.

The included 22 chapters report the latest information in the application of polymers to biological systems.

Contents

1. Semitelechelic Poly[N-(2-hydroxypropyl)-methacrylamide] for Biomedical Applications
2. Thermoresponsive Polymeric Micelles for Double Targeted Drug Delivery
3. pH/Temperature-Sensitive Polymers for Controlled Drug Delivery
4. Design of Polymeric Systems for Targeted Administration of Peptide and Protein Drugs
5. Drug Release from Ionic Drugs from Water-Insoluble Drug-Polyion Complex Tablets
6. Polychelating Amphiphilic Polymers (PAP) as Key Components of Microparticulate Diagnostic Agents
7. Bioconjugation of Biodegradable Poly(lactic/glycolic acid) to Protein, Peptide, and Anti-Cancer Drug: An Alternative Pathway for Achieving Controlled Release from Micro- and Nanoparticles
8. Elastin-Mimetic Protein Networks Derived from Chemically Crosslinked Synthetic Polypeptides
9. Genetically Engineered Protein Domains as Hydrogel Crosslinks
10. Superporous Hydrogel Composites: A New Generation of Hydrogels with Fast Swelling Kinetics, High Swelling Ratio and High Mechanical Strength
11. Structure and Solute Size Exclusion of Poly(methacrylic acid)/ Poly(N-isopropyl acrylamide) Interpenetrating Polymeric Networks
12. Thermodynamics of Water Sorption in Hyaluronic Acid and Its Derivatives
13. Photocrosslinked Polyanhydrides with Controlled Hydrolytic Degradation
14. Novel Cytokine-Inducing Macromolecular Glycolipids from Gram-Positive Bacteria
15. Hydrophobe Modified Cationic Polysaccharides for Topical Microbicide Delivery
16. Novel Antimicrobial N-Halamine Polymer Coatings
17. Design of Macromolecular Prodrug of Cisplatin Attached to Dextran through Coordinate Bond
18. Synthesis of Linear and Hyperbranched Stereoregular Aminopolysaccharides by Oxazoline Glycosylation
19. Diameter and Diameter Distributions of Poly(L-lactide) Microspheres by Ring-Opening Polymerization of L-Lactide and from Earlier Synthesized Polymers
20. Examination of Fluorescent Molecules as in situ Probes of Polymerization Reactions
21. Self-Etching, Polymerization-Initiating Primers for Dental Adhesion
22. Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates

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