edited by
Hiroshi Maeda et al

Polymer Drugs in the Clinical Stage describes important aspects of polymer science technology that will have a great impact in the future, such as:

• gene delivery to specific disease sites
• carrier polymers that respond to a stimulus or particular environment
• cancer targeted drug delivery because of the important nature of EPR-effect of polymer drugs in tumors

Polymer Drugs in the Clinical Stage is intended for students and researchers in the field of pharmacology who have particular interests in drug delivery, targeting, and formulation, as well as for oncologists and other interested clinicians.

Contents

1. Challenges in Polymer Therapeutics: State of the Art and Prospects of Polymer Drugs
2. Factors and Mechanism of "EPR" Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS
3. PEG-Adenosine Deaminase and PEG-Asparaginase
4. Peginterferon alfa-2a (40KD): A Potent Long-Acting Form of Interferon alfa-2a for the Treatment of Hepatitis C
5. PEG-Methioninase
6. Poly-(L)-Glutamic Acid-Paclitaxel (CT-2103)[XYOTAX®], a Biodegradable Polymeric Drug Conjugate: Characterization, Preclinical Pharmacology, and Preliminary Clinical Data
7. HPMA Copolymer Delivery of Chemotherapy and Photodynamic Therapy in Ovarian Cancer
8. Drug-HPMA-HuIg Conjugates Effective Against Human Solid Cancer
9. CM-Dextran-Polyalcohol-Camptothecin Conjugate: DE310 with a Novel Carrier System and its Preclinical Data
10. Polymeric Micelle Drug Carrier Systems: PEG-PAsp(Dox) and Second Generation of Micellar Drugs
11. An Interim Analysis of Phase I Clinical Trial of MCC-465, a Doxorubicin (DXR) Encapsulated in PEG-immunoliposome, in Patients with Metastatic Stomach Cancer
12. Polymer Conjugates for Imaging
13. S-Nitrosylated Polyethylene Glycol-conjugated Hemoglobin Derivative as a Candidate Material for Oxygen Therapeutics

Index

click here to see books • videos • cd-roms of related interest