edited by Harry G. Brittain
Providing essential information on the myriad physical properties that a single given compound may exhibit, Polymorphism in Pharmaceutical Solids presents a comprehensive examination of polymorphic behavior in pharmaceutical development—demonstrating with clear, practical examples how to navigate complicated crystal structures.
The first comprehensive summary of topics surrounding polymorphic behavior of compounds of interest to drug development scientists!
Designed to be both a self-study guide and a reference tool, Polymorphism in Pharmaceutical Solids:
- introduces the theory of polymorphism, explaining the occurrence of different crystalline forms of the same pure substance
- discusses preparation of different polymorphs by means of sublimation and crystallization from the melt, supercritical fluids, and liquid solutions
- explores the fusion curve and other regularities in transformations between liquid and solid phases
- deconstructs crystal axes, spheres, and other structural components of crystal lattices
- reveals methods for the generation of polymorphic materials
- illustrates the relationships among the seven crystal classes in pharmaceutical drug development
- details crystallography of dissymmetric solids
- and much more!
This superb compendium is essential reading for industrial and product development pharmacists; pharmaceutical scientists; medicinal, physical, surface, colloid, and analytical chemists and spectroscopists; and professional seminars and graduate-level courses in these disciplines.
Contents
- Theory and Origin of Polymorphism
- Application of the Phase Rule to the Characterization of Polymorphic Systems
- Structural Aspects of Polymorphism
- Structural Aspects of Hydrates and Solvates
- Generation of Polymorphs, Hydrates, Solvates, and Amorphous Solids
- Methods for the Characterization of Polymorphs and Solvates
- Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate
- Effects of Pharmaceutical Processing on Drug Polymorphs and Solvates
- Structural Aspects of Molecular Dissymmetry
- Impact of Polymorphism on the Quality of Lyophilized Products
Index
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