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Pharmaceutical Development
Book from C.H.I.P.S.

Polymorphism in Pharmaceutical Solids
Second Edition
edited by Harry G. Brittain

Polymorphism in Pharmaceutical Solids presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science.

Fully updated and expanded, this new edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.

Polymorphism in Pharmaceutical Solids now includes:

  • new chapters:
    • computational methodologies
    • high-throughput screening methods
    • pharmaceutical cocrystals
    • thermally-induced and solution-mediated phase transformations
    • amorphous solids
  • summarized topics of crystallography, preparation, and characterization
  • coverage of related topics, such as the amorphous state
Contents

Thermodynamic and Theoretical Issues

  1. Theory and Principles of Polymorphic Systems
  2. Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems
  3. Computational Methodologies: Toward Crystal Structure and Polymorph Prediction
Preparative Methods for Polymorphs and Solvatomorphs
  1. Classical Methods of Preparation of Polymorphs and Alternative Solid Forms
  2. Approaches to High-Throughput Physical Form Screening and Discovery
Structrual Properties of Polymorphs and Solvatomorphs
  1. Structural Aspects of Polymorphism
  2. Structural Aspects of Solvatomorphic Systems
  3. Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds
Characterization Methods for Polymorphs and Solvatomorphs
  1. Thermoanalytical and Crystallographic Methods
  2. Vibrational Spectroscopy
  3. Solid-State Nuclear Magnetic Resonance Spectroscopy
  4. Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate
Interconversion of Polymorphs and Solvatomorphs
  1. Solid-State Phase Transformations
  2. Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials
Special Topics Related to Polymorphism and Solvatomorphism
  1. Structural Aspects of Molecular Dissymmetry
  2. Amorphous Solids
Index

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Polymorphism in Pharmaceutical Solids
Second Edition
edited by Harry G. Brittain

2009 672 pages $298.95 + shipping
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