by Mark I. Evans
Prenatal Diagnosis provides in-depth clinical coverage of prenatal diagnosis, fetal risk, and related topics of consequence to practitioners.
Features:
- Genetic risk factors and risk assessment
- Prenatal genetic counseling
- Environmental, occupational, viral, bacterial, radiological, and other sources of fetal genetic risk
- Diagnostic methods, including the latest imaging technologies
- Strengths and weaknesses of imaging technologies
- Comprehensive exploration of the ultrasound examination
- System-by-system diagnosis of fetal abnormalities
- 350 diagnostic and other images
- Latest developments in diagnostic sampling and laboratory testing
- Counseling on abnormalities
- Approaches to management and treatment of fetal abnormalities
- Fetal surgery
- Pregnancy reduction and termination
- Reviews of classic genetics, molecular biology, and cytogenetics
- Special chapters on cross-cultural, legal, and ethical issues
Contents
Section One: Genetics & Reproductive Risks
- Principles of "Classic" Genetics
- Epidemiology of Aneuploidy
- New Genetic Concepts
- Chromosomal Aberrations
- Mendelian Genetics in Prenatal Diagnosis
- Syndrome: An Approach to Fetal Dysmorphology
- Genes and Development
- Prenatal Genetic Counseling
- Principles of Teratology
- Drugs
- The Effects of Maternal Drinking During Pregnancy
- Characterizing the Effect of Environmental and Occupational Exposures on Reproduction and Development
- Bacterial Infections and Pregnancy
- Viral Agents and Reproductive Risks
- Exposure to Ionizing Radiation During Pregnancy
- Chemotherapy in Pregnancy
Section Two: Ultrasound Diagnosis & Screening
- Overview of the Comprehensive Ultrasound Examination: An Approach to Diagnosis and Management of Fetal Anomalies
- Imaging the Fetal Brain
- Heart and Vascular Malformations
- Normal and Abnormal Findings of the Fetal Abdomen and Anterior Wall
- Genito-Urinary Tract Abnormalities
- Skeletal Dysplasia
- Biochemical Screening
- First Trimester Ultrasound Screening with Nuchal Translucency
- Second Trimester Sonographic Markers for Aneuploidy
- Color Doppler in Congenital Defects
- Doppler and Fetal Abnormalities in the Second Trimester
- Ultrasound in Multiple Gestation
- Three-Dimensional Ultrasound in Prenatal Diagnosis
- Three-Dimensional Fetal Neuroscan
- Computer and Ultrasound
- Fetal Age Determination and Growth Assessment: Their Roles in Prenatal Diagnosis
- Ultrasound Evaluation of the Placenta
Section Three: Procedures
- Amniocentesis
- Early Amniocentesis: Risk Assessment
- Chorionic Villus Sampling
- Cordocentesis
- Tissue Biopsies
- Fetal Skin Sampling and Prenatal Diagnosis of Genodermatoses
- Operative Fetoscopy
Section Four: Laboratory Diagnostics
- Cytogenetics and Molecular Cytogenetics
- Biochemical Genetics
- Molecular Diagnostics for Prenatal Diagnosis
- Molecular Screening
- Prenatal Diagnosis Using Fetal Cells From Maternal Blood
- Molecular Screening
- Clinical Proteomics
Section Five: Management of Problems
- Psychological Reaction to Prenatal Diagnosis and Loss
- Counseling for Abnormalities
- Termination of Pregnancy
- The Fetal Autopsy
- Reduction in Multiple Pregnancies
- Selective Termination
- The Obstetrical Management of Fetal Anomalies
- Assessment and Management of Neonates with Congenital Anomalies
Section Six: Fetal Therapy
- Fetal Shunt Procedures
- The Evolution of Fetal Surgery for Treatment of Congenital Diaphragmatic Hernia
- Fetal Surgery - Open: Congenital Cystic Adenomatoid Malformation
- Fetal Pharmacologic Therapy for Mendelian Disorders
- Folic Acid and Prevention of Neural Tube Defects
- Evaluation of the Fetal Cardiovascular System
- Prenatal Cardiac Therapy
- Fetal Genetic Therapy - Somatic
- Fetal Genetic Therapy - Stem Cells
Section Seven: Ethical, Legal, and Social Issues
- Pscychosocial Issues in Prenatal Diagnosis
- Ethics and Prenatal Diagnosis: Cross-Cultural Considerations
- An Ethical Framework for Fetal Therapy
- Legal Issues in Genetic Diagnosis and Counseling
- Politics and Genetic Reproductive Risks
Index
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