This basic course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy.

Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system.

Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy.

Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development.

Contents

Fundamental Principles of Pharmacology

1. Drug-Receptor Interactions
2. Pharmacodynamics
3. Pharmacokinetics
4. Drug Metabolism
5. Drug Toxicity

Principles of Neuropharmacology

6. Principles of Cellular Excitability and Electrochemical Transmission
7. Principles of Nervous System Physiology and Pharmacology
8. Cholinergic Pharmacology
9. Adrenergic Pharmacology
10. Local Anesthetic Pharmacology
11. Pharmacology of GABAergic and Glutamatergic Neurotransmission
12. Pharmacology of Dopaminergic Neurotransmission
13. Pharmacology of Central Adrenergic and Serotonergic Neurotransmission
14. Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System
15. General Anesthetic Pharmacology
16. Pharmacology of Analgesia
17. Pharmacology of Drug and Alcohol Abuse and Dependence

Principles of Cardiovascular Pharmacology

18. Pharmacology of Cardiac Rhythm
19. Pharmacology of Cardiac Contractility
20. Pharmacology of Volume Regulation
21. Pharmacology of Vascular Tone
22. Pharmacology of Hemostasis and Thrombosis
23. Pharmacology of Cholesterol and Lipoprotein Metabolism
24. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure

Principles of Endocrine Pharmacology

25. Pharmacology of the Hypothalamus and Pituitary Gland
26. Pharmacology of the Thyroid Gland
27. Pharmacology of the Adrenal Cortex
28. Pharmacology of Reproduction
29. Pharmacology of the Endocrine Pancreas
30. Pharmacology of Bone Mineral Homeostasis

Principle sof Chemotherapy

31. Principles of Antimicrobial and Antineoplastic Pharmacology
32. Pharmacology of Bacterial Infections: Central Dogma Processes
33. Pharmacology of Bacterial Infections: Cell Wall Synthesis
34. Pharmacology of Fungal Infections
35. Pharmacology of Parasitic Infections
36. Pharmacology of Viral Infections
37. Pharmacology of Cancer: DNA Synthesis, Stability, and Maintenance
38. Pharmacology of Cancer: Signal Transduction
39. Principles of Combination Chemotherapy

Principles of Inflammation and Immune Pharmacology

40. Principles of Inflammation and the Immune System
41. Pharmacology of Eicosanoids
42. Histamine Pharmacology
43. Pharmacology of Hematopoietic and Immune Cell Stimulation
44. Pharmacology of Immunosuppression
45. Integrative Inflammation Pharmacology: Peptic Ulcer Disease
46. Integrative Inflammation Pharmacology: Asthma
47. Integrative Inflammation Pharmacology: Gout

Fundamentals of Drug Development and Regulation

48. Drug Discovery and Preclinical Development
49. Clinical Drug Evaluation and Regulatory Approval
50. Detection and Management of Adverse Events in Marketed Drugs

Poisoning by Drugs and Environmental Toxins

51. Poisoning by Drugs and Environmental Toxins

Frontiers in Pharmacology

52. Pharmacogenomics
53. Protein-Based and Gene Therapies
54. Drug Delivery Modalities

Index

Accompanies Principles of Pharmacology Workbook.

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ORDER NOW Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy Second edition edited by David E. Golan 2008 (available now) • 985 pages • $69.95 + shipping Texas residents please add 6.75 % sales tax