This is the first book to provide a comprehensive and unique overview of proteomic and genomic analysis with a specific focus on cardiovascular disease. In its entirety, this book gives tantalizing glimpses into the incredibly dynamic and complex working of a cell and the cardiovascular system as it adapts to stress, its environment, and disease.

Features

• Highlights a variety of proteomic and geomic strategies, their essential technologies along side a glimpse into future technological platforms.
• Address important current issues, limitations and promise, in the application of proteomics and genomics, specifically with respect to disease.
• Provide new and exciting insights into the biochemical and cellular mechanisms underlying a range of cardiovascular diseases.
• Describe translational science in which proteomic-and genomic-derived information is used for clinical discovery and validation of novel biomarkers and therapeutic targets of disease.

Contents

1. Genomics
   1. Large Scale Expression Profiling in Cardiovascular Disease Using Microarrays: Prospects and Pitfalls
   2. Global Genomic Analyses of Cardiovascular Disease: A Potential Map or Blind Alley?
   3. Heart Failure: A Genomics Approach
   4. Principles of cDNA Microarrays as Applied in Heart Failure Research
   5. Gene Profiling in the Heart by Subtractive Hybridization
   6. DNA Mircoarray Gene Profiling: A Tool for the Elucidation of Cardioprotective Genes
   7. Pitfalls Associated with cDNA Microarrays - A Cautionary Tale
   8. Application of Biologic Skepticism to Analysis of Expression Phenotypes
   9. Genes Involved in Atherosclerosis and Plaque Formation

2. Proteomics
   10. Gene Expression Profiling in Pulmonary and Systemic Vascular Cells Exposed to Biomec hanical Stimuli
   11. Proteomics, a Step Beyond Genomics: Applications to Cardiovascular Disease
   12. Mass Spectrometry - A Powerful Analytical Tool
   13. Differential Expression Proteomic Analysis Using Isotope Coded Affinity Tags
   14. Protein Chip T echnology in Proteomics Analysis
   15. Recent Applications of Functional Proteomics: Investigations in Smooth Muscle Cell Physiology
   16. Identification of Targets of Phosphorylation in Heart Mitochondria
   17. Proteomic Characterization of Protein Kinase C Signaling Tasks in the Heart
   18. Identification of Secreted Oxidative Stress-induced Factors (SOXF) and Associated Proteins: Proteomics in Vascular Biology
   19. Myofilament Proteomics: Understanding Contractile Dysfunction in Cardiorespiratory Disease

3. Future Perspectives
   20. Genomics Perspective for Drug Discovery
   21. Proteomics: A Post-Genomic Platform for Drug Discovery and Development

Subject Index

click here to see books • videos • cd-roms of related interest