• Covers the cellular and biochemical aspects of iron metabolism
• Details current developments in molecular and cellular biology and genetics
• Outlines molecular mechanisms responsible for the coordinated control of proteins
• Analyzes progress in the area of iron storage and iron transporter proteins
• Provides figures illustrating the expression/function of the various genes involved in iron metabolism in various cell types

Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins.

Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature.

The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.

Contents

1. Iron Absorption
   • Introduction
   • Iron Requirements
   • Iron Digestion
   • Iron Absorption
   • Physiologic Regulation of Iron Absorption
   • Iron Bioavailability
   • Absorption of Heme Iron

2. Iron and Cell Proliferation: Mechanisms and Applications in Cancer Therapy
   • Introduction
   • Ribonucleotide Reductase: A Key Enzyme in the Control of DNA Synthesis
   • Iron and Cell Cycle Control
   • Inhibition of Cell Proliferation by Agents that Reduce Cellular Iron Incorporation
   • Iron and Cancer

3. Lactoferrin
   • Introduction
   • Biochemistry and Molecular Biology of Lactoferrin
   • Lactoferrin Receptors
   • Functions of Lactoferrin
   • Lactoferrin Expression in Neutrophils and Mammary Glands
   • Lactoferrin Expression during Development

4. Transferrin
   • Introduction
   • Comparative Analysis of the Structures of Transferrin Family Proteins
   • Transferrin Genetic Variants
   • Biochemical Properties of Serum Transferrin
   • Transferrin Gene Expression
   • Transferrin and Microbiology
   • Transferrin as a Growth Factor
   • Congenital Atransferrinemia
   • Transferrin as a Transporter of Drugs

5. Transferrin Receptor
   • Introduction
   • General Features
   • Molecular Biology
   • Transferrin Receptor Glycosylation
   • Trandferrin Receptor Endocytosis
   • Transferrin Receptor Phosphorylation
   • Intracellular Pools of Transferrin Receptors
   • Effect of Ca2+ and Oxidation on Transferrin Receptor Internalization
   • Tissue Distribution and Expression on Selected Cell Types
   • Regulation of Transferrin Receptors
   • Expression and Regulation in Different Cell Types
   • Interaction between Transferrin Receptors and HFE: The Class I MHC-Related Protein Mutated in Hereditary Hemochromatosis
   • A General Overview of Iron Uptake Mechanisms in Various Cell Types

6. Soluble Transferrin Receptor
   • Introduction
   • Generation of Soluble Transferrin Receptor
   • Circulation in Human Serum
   • Clinical Relevance

7. Alternative Iron Uptake Systems
   • Transferrin-Idependent Iron Uptake
   • Proton-Coupled Metal Ion Transporter
   • Mechanisms of Iron Transport in and out of Cells: Role of Ceruloplasmin
   • HFE
   • Melanotransferrin

8. Iron-Responsive Elements and Iron Regulatory Proteins
   • Introduction: The Discovery of Iron Responsive Elements (IRE) and Iron Regulatory Proteins (IRP)
   • Secondary and Tertiary Structures of IRE
   • Iron Regulatory Proteins
   • Role of IRP in Mediating Transferrin mRNA Stability
   • Role of IRP in the Control of Ferritin Translation
   • Evolution of IRPs
   • Regulation of IRP Activity by Nitric Oxide
   • Regulation of IRP by Oxidative Stress
   • Role of Phosphorylation in the Control of IRP Activity
   • Role of Heme in the Regulation of IRP Activity
   • IRPs Coordinate In Vivo Iron Metabolism
   • Tissue-Dependent Regulation of IRP Activity

9. Ferritin
   • Introduction
   • Evolution of Ferritins
   • Three-Dimensional Structure of Ferritin
   • Ferroxidase Activity of Ferritin
   • Role of Phosphate on Iron Oxidation and Iron-Core Formation
   • Iron Release from Ferritin
   • Hemosiderin
   • Serum Ferritin
   • Ferritin Genes
   • Transcriptional Control of Ferritin Gene Expression
   • Ferritin and Endothelium
   • Ferritin in Tumor Cells
   • Ferritin Expression and Function in Selected Tissues
   • Unexpected Functions of Ferritin

Index

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