The chapters of this book describe all relevant aspects of intermolecular interactions in great detail.

It shows the basic aspects of ligand-protein interaction which may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug.

This book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.

Contents:

• Prediction of non-bonded interactions in drug design
• Introduction to molecular recognition models
• Experimental approaches to determine the thermodynamics of protein-ligand interactions
• The biophore concept
• Receptor-ligand interaction
• Hydrogen bonds in protein-ligand complexes
• Principles of enzyme inhibitor design
• Tailoring protein scaffolds for ligand binding
• Small molecule screening on chemical microarrays

Index

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