Proteinase and Peptidase Inhibition presents updated progress reports on the characterization of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs.

Introductory chapters deal with the broad enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understanding how inhibition of different targets can lead to the same therapeutic outcomes.

Proteinase and Peptidase Inhibition is a valuable reference book that will appeal to both academic and industrial researchers in the fields of medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.

Contents

1. Enzyme Classes and Mechanisms
2. Regulatory Mechanisms for Proteinase Activity
3. Matrix Metalloproteinases (MMPs)
4. Proteasomes
5. Cathepsins
6. Calpain
7. Human Neutrophil Elastase Inhibitors
8. Thrombin
9. Inhibitors of Factor VIIa, Factor IXa, and Factor Xa as Anticoagulants
10. The Urokinase-Type Plasminogen Activator (uPA) System: A New Target for Tumor Therapy
11. Proteinases Involved in Amyloid ß-Peptide (Aß) Production and Clearance
12. Herpes Virus and Cytomegalovirus Proteinase
13. Human Rhinovirus 3C Proteinase Inhibitors
14. Aminopeptidases
15. The Hepatitis C Virus NS3 Serine-Type Proteinase
16. Zinc Metallopeptidases
17. HIV Aspartate Proteinase: Resistance to Inhibitors
18. Proteases of Protozoan Parasites for Proteinase Activity

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