Radionuclide Peptide Cancer Therapy offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers.

Features:

• Covers practical aspects of this new anti-cancer therapy
• Provides a comprehensive set of chapters by experts in the field, providing basic background, the latest clinical applications, dosimetric aspects, and regulatory requirements
• Reviews the technology of peptide production, aspects of radiolabeling, and the results of their clinical applications obtained at acknowledged institutions
• Includes two sections that present novel strategies to enhance the spectrum of peptide application

Contents

Theory and Production of Peptides for Radionuclide Therapy

• Peptide Structure and Analysis
• Molecular Pharmacology of Receptors
• Receptors Distribution and Biochemical Characterization

Radiolabeling Mechanisms and Strategies

• Developments of Radiolabeled Peptides
• Receptor Targeting for Tumor Therapy with Radiopeptides
• New Radionuclides for Peptide Therapy
• Pre-Clinical Comparison of Radiolabeled Peptides for Radionuclide Therapy

Clinical Therapeutic Applications

• Phase I Therapeutic Studies
• Response to Treatment with Radiolabeled Peptides
• Receptor Radionuclide Therapy: From 90Y to 177Lu Labeled Peptides
• Therapeutic Potential of Radiolabeled Peptides with Beta and Alpha Emitters
• Receptor-Mediated Radionuclide Therapy: The European Institute of Oncology Experience

Dosimetric Aspects and Regulatory Requirements

• Radiation Dosimetry in Preparation to Therapy
• Dosimetry and Critical Organs
• Regulatory Requirements for Therapy Trials

Future Perspectives

• Advances in the Field of Radiopeptides for Therapy

Index

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