Radiotracers in Drug Development presents classical radioactive measurement methods and principles of radioactive decay as a foundation for understanding the latest advances.

Features:

• Serves as the only comprehensive source of information that covers the how-tos of employing radiotracers in drug development
• Covers the principles of radioactive decay and measuring of radioactivity
• Discusses how to measure low levels of tracers with Accelerator Mass Spectrometry equipment
• Includes material on Radioluminography, Positron Emission Tomography, and gamma -scintigraphy
• Presents examples and illustrations to show how the collected data is used in drug research

Contents

1. Radiotracers and Drug Registration
2. Radioactivity and Radiotracers
3. The Study of Drug Metabolism Using Radiotracers
4. DNA Binding, Isotope Dilution, and Other Uses of Radiotracers
5. Quantitative Whole-Body Autoradiography (QWBA)
6. Scintillation Counting
7. Statistics in Liquid Scintillation Counting
8. Instrumentation for Detection of Radioactivity
9. Sample Preparation for Liquid Scintillation Counting
10. Biomedical Accelerator Mass Spectrometry
11. Positron Emission Tomography
12. Gamma Scintigraphy and SPECT

Index

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