edited by Paul Leff
Employing a wide range of examples from G-protein-coupled receptors and ligand-gated
ion channels, this detailed, single-source reference illustrates the principles
of pharmacological analysis and receptor classification that are the basis of
rational drug design.
Receptor-Based Drug Design explains the experimental and theoretical methods used to characterize interactions between ligands and receptors—providing the pharmacological
information needed to solve treatment problems and facilitate the drug design process!
Demonstrating the achievements of the receptor-based approach in therapeutics
and indicating future directions, Receptor-Based Drug Design
- introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors
- shows how to assess agonist concentration-effect curve data
- discusses radioligand binding assays
- presents new in vitro multiarray assays for G-protein-coupled receptors
- explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions
- examines the role of electrophysiology in finding new drugs and drug targets
- describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment
- outlines the rationale for using angiotensin receptor antagonists
- and more!
Contents
- Principles and Measurement of Drug-Receptor Interactions
The Characterization and Classification of Receptors
Functional Methods for Quantifying Agonists and Antagonists
Quantification of Receptor Interactions Using Binding Methods
Drug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors
The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions
- Receptor-Based Drugs in Medicine
Selective Adrenergic and Glucocorticoid Treatments for Asthma
Serotonin 5-HT1B/D Receptor Agonists
Histamine H2-Receptor Antagonists
Angiotensin Antagonists
- Experimental and Emerging Drugs
-Adrenoceptor Agonists and Antagonists
P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases
Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility
NMDA Receptor Antagonists
- New Trends in Drug Design
Computational Chemistry in Receptor-Based Drug Design
Recombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery
Inverse Agonists and G-Protein-Coupled Receptors
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