From Protein Modifications to Cellular Dysfunction and Diseases
by Isabella Dalle-Donne
Redox Proteomics brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics.
Features:
- The role of oxidized proteins in various disorders
- Pioneering studies on the development of redox proteomics
- Analytical methodologies for identification and structural characterization of proteins affected by oxidativ/nitrosative modifications
- The response and regulation of protein oxidation in different cell types
- The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease
Contents
Oxidatively Modified Proteins and Proteomic Technologies
- Chemical Modification of Proteins by Reactive Oxygen Species
- The Chemistry of Protein Modifications Elicited by Nitric Oxide and Related Nitrogen Oxides
- Mass Spectrometry Approaches for the Molecular Characterization of Oxidatively/Nitrosatively Modified Proteins
- Thiol-Disulfide Oxidoreduction of Protein Cysteines: Old Methods Revisited for Proteomics
- Carbohydrated Proteins and Their Implication in Physiology and Pathology
- S-Nitrosation of Cysteine Thiols as a Redox Signal
- Detection of Glycated and Glyco-Oxidated Proteins
- MudPIT (Multidimensional Protein Identification Technology) for Identification of Post-translational Protein Modifications in Complex Biological Mixtures
- Use of a Proteomic Technique to Identify Oxidant-Sensitive Thiol Proteins in Cultured Cells
- ICAT (Isotope-Coded Affinity Tag) Approach to Redox Proteomics: Identification and Quantification of Oxidant-Sensitive Protein Thiols
- Quantitative Determination of Free and Protein-Associated 3-Nitrotyrosine and S-Nitrosothiols in the Circulation by Mass Spectrometry and Other Methodologies: A Critical Review and Discussion from the Analytical and Review Point of View
Cellular Aspects of Protein Oxidation
- The Covalent Advantage: A New Paradigm for Cell Signaling Mediated by Thiol Reactive Lipid Oxidation Products
- Early Molecular Events during Response to Oxidative Stress in Human Cells by Differential Proteomics
- Oxidative Damage to Proteins: Structural Modifications and Consequences in Cell Function
- Oxidative Damage and Cellular Senescence: Lessons from Bacteria and Yeast
- Proteins as Sensitive Biomarkers of Human Conditions Associated with Oxidative Stress
- Degradation and Accumulation of Oxidized Proteins in Age-Related Diseases
- Redox Proteomics: A New Approach to Investigate Oxidative Stress in Alzheimer's Disease
- Oxidized Proteins in Cardiac Ischemia and Reperfusion
- Proteome Analysis of Oxidative Stress: Glutathionyl Hemoglobin in Diabetic and Uremic Patients
- Glyco-oxidative Biochemistry in Diabetic Renal Injury
- Quantitative Screening of Protein Glycation, Oxidation, and Nitration Adducts by LC-MS/MS: Protein Damage in Diabetes, Uremia, Cirrhosis, and Alzheimer's Disease
- Protein Targets and Functional Consequences of Tyrosine Nitration in Vascular Disease
- Oxidation of Artery Wall Proteins by Myeloperoxidase: A Proteomics Approach
- Oxidative Stress and Protein Oxidation in Pre-Eclampsia
- Involvement of Oxidants in the Etiology of Chronic Airway Diseases: Proteomic Approaches to Identify Redox Processes in Epithelial Cell Signaling and Inflammation
- Sequestering Agents of Intermediate Reactive Aldehydes as Inhibitors of Advanced Lipoxidation End-Products
Index
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