This book is a single-source reference that furnishes up-to-date examinations of schizophrenia and related psychotic disorders as well as the clinical effects and mechanisms of the action of antipsychotic medications-highlighting the new generation of substances that act on 5HT₂A receptors.

Contents

1. The Treatment of Psychotic Disorders: The Search for Effective and Safe Long-Term Treatment
   
2. Ongoing Research in the Treatment of Schizophrenia
   
3. History of Antidopaminergic Neuroleptics
   
4. Serotonin Receptor Subtypes: Possible Roles and Implications in Antipsychotic Drug Action
   
5. The Role of Serotonin in Schizophrenia and the Mechanism of Action of Antipsychotic Drugs
   
6. Serotonin Mechanisms in Antipsychotic Treatment: Evidence from Drug Discrimination Studies
   
7. Dopamine, Serotonin, and Their Interactions in Schizophrenia
   
8. Chemistry and Pharmacology of Drugs Acting on Both 5HT₂- and D₂- Receptors
   
9. Positron Emission Tomography Studies of 5HT₂-Receptors
   
10. Assessment of Negative Symptoms: Development of the PANSS
    
11. Biochemical Markers for Negative Symptoms in Schizophrenia
    
12. Understanding the Relationship Between Extrapyramidal Side Effects and Tardive Dyskinesia
    
13. Risperidone: An Overview of Animal Pharmacology, Toxicology, and Pharmacokinetics
    
14. Clinical Pharmokinetics of Risperidone
    
15. The Clinical Development of Risperidone
    
16. The Treatment of Schizophrenia: Comparative Studies With Placebo, Haloperidol, and Risperidone
    
17. Risperidone in Comparison with Various Treatments of Schizophrenia
    
18. Extrapyramidal Side Effects of Neuroleptic Medication: Focus on Risperidone
    
19. Guidelines for the Practical Use of Risperidone

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