Silicon-mediated Transformations of Functional Groups

by Helmut Vorbrüggen

In the first work to comprehensively cover this all-important topic, the recognized expert Helmut Vorbrüggen provides both organic and bioorganic chemists with much new and valuable information for preparative synthesis.

Although every organic chemist may be familiar with different aspects of silylation for the protection of functional groups, this book covers the concept of protection while simultaneously silylating-activating various functional groups, such as amides and ureas. This novel methodology opens thus numerous synthetic pathways while effecting the elimination of water in it volatile persilylated form under rather mild reaction conditions, which are often advantageous compared to conventional methods.

The compact form and clear structure of this monograph make this a long-awaited ready reference.

Contents

1. Introduction
2. Techniques for Preparative Silylations—Desilylations
3. Preparation and Properties of Silyloxy Leaving Groups
4. Reactions of Free and Derivatized Carboxylic Acids and Carbon Dioxide
5. Reactions of Aldehydes and Ketones
6. Reactions of Alcohols, Silyl Ethers, Epoxides and Haloalkanes
7. Reactions of N-O Systems
8. Reactions of S-O and Se-O Systems
9. Cyclizations and Ring Enlargements
10. Base-catalyzed, Acid-catalyzed and Thermal Eliminations of Trimethylsilanol. Peterson Reactions
11. Formation of Carbon-Phosphorous Double Bonds
12. Reductions and Oxidations
13. Dehydration-Halogenation-Activation and Silylation of Inorganic and Organic Salts and Metallorganic Compounds
14. Formation of Organic and Inorganic Polymers

Appendix
Subject Index
Author Index

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