Stereoselective Biocatalysis explains the specific ways that biocatalysis outperform chemical catalysis by:

• utilizing ambient temperature and atmospheric pressure to minimize problems of isomerization, racemization, and epimerization
• employing microbial cells and enzymes that can be immobilized and reused over many cycles
• overexpressing enzymes for greater economy and efficiency

Contents

• Stereoselective synthesis using hydantoinases and carbamoylases
• Aminoacidase-catalyzed preparation and further transformations of enantiopure alpha-hydrogen- and alpha,alpha-disubstitute alpha-amino acids
• Chemoenzymatic synthesis of pheromones, terpenes and other bioregulators
• Stereoselective biocatalysis for synthesis of some chiral pharmaceutical intermediates
• Stereoselective hydroxylation reactions
• Regio- and stereoselective microbial hydroxylation of terpenoid compounds
• Microbial epoxidation - application in biotechnology
• Stereoselective syntheses using microbial epoxide hydrolases
• Enzymatic asymmetric synthesis using aldolases
• Decarboxylases in stereoselective catalysis
• Biocatalysis in the enantioselective formation of chiral cyanohydrins, valuable building blocks in organic synthesis
• Hydroxynitrile lyases in stereoselective synthesis
• Production of chiral beta-hydroxy acids and its application in organic syntheses
• Stereoselective synthesis of chiral compounds using whole-cell biocatalysis
• Choice of biocatalyst in the development of industrial biotransformations
• Chiral synthons by enzymatic acylation and esterification reactions
• Stereoselective nitrile-covering enzymes
• Enzyme-mediated decarboxylation reactions in organic synthesis
• Yeast-mediated stereoselective biocatalysis
• Biocatalytic synthesis of steroids
• Biocatalytic synthesis of enantiopure compound using lipases
• Chemoenzymatic preparation of enantiomerically pure S(+)-2-arylpropionic acids with anti-inflammatory activity
• Biocatalytic production of pravastatin, an antiocholesterol drug
• Application of PEG-modified enzymes in biotechnological processes
• New avenues to high-performance immobilized biosystems - from biosensors to biocatalysts
• Enzymatic protecting group techniques in organic synthesis
• Enzymatic reactions in supercritical carbon dioxide
• Dehydrogenases in the synthesis of chiral compounds
• Stereoselective microbial Baeryer-Villiger oxidations

Index

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