Stoichiometric Asymmetric Synthesis is extensively referenced and so provides a convenient point of entry to the research literature.

Stoichiometric Asymmetric Synthesis provides, at postgraduate student level, an accessible introduction to stoichiometric asymmetric synthesis.

Contents

1. Additions to Carbonyl Compounds

• Nucleophilic Addition to Chiral Carbonyl Compounds
• Addition of Chiral Nuclephiles to Carbonyl Compounds
• Asymmetric Reduction

2. Formation and Alkylation of Enolates

• Alkali Metal Enolates
• Stereoselective Enolate Oxidations and Amination
• Formation and Reaction of Other Enolates

3. Substrate-Directed Aldol Reactions

• The Mechanistic Basis of Selectivity in Aldol Reactions
• Reactions of Lithium Enolates
• Reactions of Boron Enolates
• Reactions of Titanium, Zirconium and Tin Enolates
• Mukaiyama Aldol Reactions

4. Reagent-Controlled Aldol Reactions

• Natural-Production-Derived Ligands
• Synthetic C(2) Sysmmetric Ligands

5. Allylation and Crotylation Reactions

• Addition of Achiral Allyl and Crotylmetal Reagents to Chiral Aldehydes
• Addition of Chiral Allyl and Crotylmetal Reagents to Achiral Aldehydes
• Addition of Chiral Allyl and Crotylmetal Reagents to Chiral Aldehydes

6. Pericyclic Processes

• Asymmetric Diels-Alder Reactions
• Asymmetric 1,3-Dipolar Cycloadditions
• Asymmetric (3,3) Rearrangements
• Asymmetric (2,3)-Wittig Rearrangements
• Asymmetric Ene Reactions

7. Reactions of Alkenes

• Asymmetric Hydroboration
• Asymmetric Conjugate Addition

8. Free Radical Processes

• Factors Affecting the Selectivity of Radical Reactions
• Stereocontrol in the Formation of Cyclic Systems
• Stereocontrol in the Formation of Acyclic Systems

Index

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