edited by Peter York,
Uday B. Kompella
and Boris Shekunov

Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products—from drug powders for respiratory delivery to drug delivery systems for controlled release.

Contents

1. Introduction: Changing Needs in Drug and Delivery System Design and Development
1. Fundamentals
   2. Chemistry and Materials Design for Pharmaceutical Applications
   3. Phase Equilibrium in Solid-Liquid-Supercritical Fluid Systems
   4. Mechanisms of Particle Formation Using Supercritical Fluids
   5. Methods of Particle Production

2. Drug Delivery Applications
   6. Colloid and Interface Science for CO2-based Pharmaceutical Processes
   7. Production of Powders for Respiratory Drug Delivery
   8. Control of Physical Forms of Pharmaceutical Substances
   9. Supercritical Fluid Impregnation of Polymers for Drug Delivery
   10. Formulation of Controlled Drug Release Systems
   11. Processing of Biological Materials

3. Other Applications and Scale-Up Issues
   12. Asymmetric Catalysis in Supercritical Fluids
   13. Analytical and Semi-Preparative Supercritical Fluid Chromatography in Drug Discovery
   14. Drug Extraction
   15. Development and Potential of Critical Fluid Technology in the Neutraceutical Industry
   16. Scale-Up Issues for Supercritical Fluid Processing in Compliance with GMP

Index

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