Synthesis of Carbohydrates through Biotechnology describes rapid developing and cutting edge new technologies in glycoscience. It discusses the engineering of glycosyltransferases and carbohydrate-active enzymes for preparative purposes, structure-function studies, chemo-enzymatic carbohydrate synthesis, and new approaches on carbohydrate-based drug discoveries. These new approaches combine advantages of molecular biology, genetic engineering and chemistry, and provide access to synthetic carbohydrates.

Synthesis of Carbohydrates through Biotechnology covers the latest progress on production of carbohydrates using biotechnology.

Researchers and students in chemistry, biochemistry, bioengineering, carbohydrate chemistry, and glycoscience will find this an invaluable resource.

Contents

1. Approaches to the Enzymatic Carbohydrate Synthesis
2. Exploring Carbohydrate Diversity Through Automated Synthesis
3. Glycosynthesis for Drug Discovery: Globo H Synthesis by OPopS
4. Probing the Antigenic Diversity of Sugar Chains
5. Chemoenzymatic Synthesis of Lactosamine and (a2->3) Sialylated Lactosamine Building Blocks
6. Synthesis of Bioactive Glycopeptides through Endoglycosidase-Catalyzed Transglycosylation
7. Strategies for Synthesis of an Oligosaccharide Library Using a Chemoenzymatic Approach
8. Artificial Golgi Apparatus: Direct Monitoring of Glycosylation Reactions on Automated Glycosynthesizer
9. Sugar Engineering with Glycosaminoglycan Synthases
10. Production of Oligosaccharides Using Engineered Bacteria: Engineering of Exopolysaccharides from Lactic Acid Bacteria
11. Production of Oligosaccharides by Coupling Engineered Bacteria
12. Synthesis of Glycoconjugates through Biosynthesis Pathway Engineering

Index

click here to see books • videos • cd-roms of related interest