Technetium-99m Pharmaceuticals provides an account of the multidisciplinary nature of ^99mTc-pharmaceuticals and their application in diagnostic nuclear medicine.

Technetium-99m Pharmaceuticals contains information on the chemistry of technetium and offers new concepts for labeling biologically active molecules.

Contents

Part 1

1. Drug Safety
   • Quality Control
   • Quality Standards
   • Quality Assurance
   • Quality Control of Kit Products
   • European Economic Community Directives and Regulations
2. Technetium in Medicine
   • ^99mTechnetium Chemistry
3. Stannous Chloride in the Preparation of ^99mTc Pharmaceuticals
   • Stannous Chloride: The Preferred Reducing Agent for Tc Pharmaceuticals
4. Quality Assurance of Radiopharmaceuticals
5. Performance and Quality Control of the ⁹⁹Mo/^99mTc Generator
   • The Equilibrium State
   • Performance of the ⁹⁹Mo/^99mTc Generator System
   • Purity of Generator Eluate
   • Methods and Results
6. Preparation of Technetium ^99mTc Pharmaceuticals
   • Kit Preparation
7. Lyophiliztion Technique for Preparing Radiopharmaceutical Kits
   • History of the Lyophilization Technique
   • Principles of Lyophilization
   • Apparatus for Freezer-Drying
8. Cellular Labeling with ^99mTc Chelates: Relevance of In Vitro and In Vivo Viability Testing
   • Red Blood Cells
   • Platelets
   • White Blood Cells
   • Stem Cells
9. Quality Control Methods of ^99mTc Pharmaceuticals
   • Determination of Chemical Purity
   • Determination of Tin (II)
   • Sterility Testing of Radiopharmaceuticals
   • Pyrogen Testing of Radiopharmaceuticals
10. Other Tc Isotopes: ^94mTc as a Potential Substitute in Positron Emission Tomography Investigation
    • Methods of Production
    • Methods of Separation
11. The Rules Governing Medicinal Products for Human Use in the European Union

• European Economic Community Directives and Regulations
• The European Pharmacopeia
• European Union Legislation Concerning New Drug Development

Part 2

12. Monographs of ^99mTc Pharmaceuticals
    • ^99mTc-Pertechnetate
    • ^99mTc-Labeled Human Serum Albumin
    • ^99mTc-Labeled Colloids
    • ^99mTc-Labeled Myocardial Perfusion Agents
    • ^99mTc-Labeled Brain Perfusion Agents
    • ^99mTc-Labeled Leukocytes
    • ^99mTc-Labeled Bone Imaging Agents
    • ^99mTc-Labeled Hepatobiliary Agents
    • ^99mTc-Labeled Peptides
    • ^99mTc-Labeled Monoclonal Antibodies

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ORDER NOW Technetium-99m Pharmaceuticals Preparation and Quality Control in Nuclear Medicine edited by Ilse Zolle 2007 • 345 pages • $168.00 + shipping Texas residents please add 6.75 % sales tax