Topical Drug Delivery Formulations
edited by David W. Osborne

Integrating the latest insights with established principles, this important book guides readers in the development of highly effective, nontraditional topical drug delivery formulations.

Focusing on liquid or semisolid topicals with information applicable to transdermal patch drug delivery, Topical Drug Delivery Formulations

• Helps formulators design vehicles that optimize drug-skin or prodrug-skin interactions, release drugs for sustained periods of time, and target specific skin regions

• Emphasizes recent advances in the understanding of the skin as a barrier to percutaneous absorption and how it can be compromised by penetration enhancers

• Demonstrates how to design stability and in-vitro testing

• Explains methods necessary for evaluating topical products

• And much more!

The united effort of leading academic and industrial scientists, this outstanding reference is essential reading for formulation, surfactant, and industrial scientists; physical and industrial pharmacists; colloid, surface, physical, and cosmetic chemists; pharmacologists, dermatologists, toxicologists, and industrial health specialists; and students in the above disciplines.

Contents

1. Principles of Skin and Formulation Interactions
   1. Practical Considerations for Topical Drug Formulations With and Without Enhancers
   2. The Importance of Epidermal Lipids for the Stratum Corneum Barrier
   3. Stratum Corneum Structure and Transport Properties
   4. Penetration Enhancer Incorporation in Bilayers
   5. The Influence of Skin Surface Lipids on Topical Formulations
   6. Immunology of the Skin

2. Drug Formulation Selection and Testing for Topical Use
   7. Computational Methods for Prodrug or Drug Analogue Selection Optimized for Percutaneous Delivery
   8. Kinetic Considerations in the Design of Surfactant Based Topical Formulations
   9. The Use of Phase Behavior and Laboratory Robotics for the Optimization of Pharmaceutical Topical Formulations
   10. General Considerations for Stability Testing of Topical Pharmaceutical Formulations
   11. In Vitro Testing of Topical Pharmaceutical Formulations
   12. Drug Delivery from Topical Formulations: Theoretical Prediction and Experimental Assessment
   13. The Use of Solubility Parameters of Drug and Vehicle to Describe Skin Transport
   14. Use of an Epidermal Culture for Cutaneous Toxicity Studies

3. Nontraditional Topical Drug Delivery Formulations
   15. The Microsponge: A Novel Topical Programmable Delivery System
   16. Liposome-Based Vehicles for Topical Delivery
   17. Surfactant Association Colloids as Topical Drug Delivery Vehicles
   18. Gel Dosage Forms: Theory, Formulation, and Processing
   19. Using Silicones in Topical Products

Index

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