This up-to-date reference/text comprehensively presents and reviews techniques for testing antibacterial compounds, providing the ways of getting products approved by the FDA and the means of servicing expanding markets.
This is an indispensable reference for cosmetic scientist and technologists, quality assurance personnel, food scientists and technologists, topical antimicrobial product manufacturers, medical infection control scientists, microbiologists, and virologists.
Topical Antimicrobial Testing and Evaluation takes a unique approach of:
- summarizing new compounds for dissolving or breaching bacteria capsules and membranes
- interpreting standards set by federal regulatory agencies such as the FDA
- explaining how to reduce the threat to immunologically compromised patients from infectious
disease in healthcare environments
- exploring the skin and its benign "resident" microorganisms, as well as skin exfoliation as
a means of eliminating potentially pathogenic "nonresident" microbes
- examining immediate, persistent, and residual effects of antimicrobials and their
relationship with purpose-specific topical agents
- evaluating the importance of experimental design
- illustrating ways of correcting certain biases latent in some experimental methods
- describing parametric statistical models such as analysis of variance, analysis of
covariance, and exploratory data analysis, as well as nonparametric methods, demonstrating
their application with a wide variety of examples
- and more!
Contents:
- General Approach to Developing Topical Antimicrobials
Holonic Quadrant Model
A Chronic Problem: Reductionism
- Skin Properties
Structure
The Epidermis
The Dermis
Dermal Vascularization
The Tissue Fluids
- Skin Microbiology
Etiology of Infectious Diseases
The Bacterial Cell
Mycology
Viruses
- Current Topical Antimicrobials
Iodine Complexes
Chlorhexidine Gluconate
Parachlorometaxylenol (PCMX)
Alcohols
Triclosan
- Measurement of Antimicrobial Action of Topical Antimicrobials
General Performance Characteristics
The Research Situation
Microbiological Methodology
Statistical Methods Used to Evaluate the Study
New Product Development Applications
- Epistemological Requirements in Evaluating the Effects of Specific Treatments
Experimental Strategy
Choosing Qualitative or Quantitative Methods
Statistical Methods
Statistical Model-Building and Analysis
Parametric Statistics
Non-parametric Statistics
Qualitative Research Designs
Phenomenological Designs
Heuristic Designs
Historical Research Design
Evaluative Research Design
- Evaluation Strategies and Sample Working Protocols
Consumer Antimicrobial Products
Healthcare Personnel Handwash Evaluations
Proposed Antimicrobial Handsoap Evaluation
Sample Protocols (to be modified as required)
General-use Handwash Evaluation
Evaluating Antimicrobial Body Soaps/Lotions
Foodhandler Antimicrobial Handwash Evaluation
Medical/Healthcare Industry Antimicrobials
- Overview of Statistical Methods
Purpose of the Evaluation
Introduction to Statistical Inference
Analysis of Variance (ANOVA)
Kruskal-Wallis Statistic
Index
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