Understanding Carcinogenesis presents both the basic and the clinical areas while retaining a simple and concise style.

Features:

• Includes a description of genes involved in the process of carcinogenesis and concludes with more complex phenomena of tumor biology, such as the role of the tumor stroma and the metastatic process
• Includes pharmacogenomics and viral carcinogenesis. In addition, he describes human and animal models of the disease, emphasizing their advantages and their limitations, rounding off with unifying concepts, as well as ongoing and future perspectives
• Makes good use of simple graphs to underline the notions described in the text, a feature that particularly aids comprehension

Contents

Basic Aspects

• Some Introductory Concepts in Tumor Biology: Clonal Evolution and Autonomy versus Non-autonomy of Cancer Cells
• The Cell’s Life and Death: Cell Cycle, Senescence and Apoptosis

Genes Involved in Carcinogenesis

• Oncogenes
• Tumor-suppressor Genes
• Genomic Instability
• ATwist in the (Genetic) Tail: Cancer Epigenetics
• Nonautonomous Interactions in Carcinogenesis: Role of the Tumor Stroma
• Telomerase and Cellular Immortality
• Tumor Angiogenesis
• Metastasis

Specific Topics

• Tissue Context as a Determinant of the Tumor-suppressive or Oncogenic Function of Certain Genes
• Cancer Stem Cells
• Determination of Therapeutic Efficacy – Pharmacogenomics
• Certain Chemicals Induce Cancer: Chemical Carcinogenesis
• Hormones and Cancer
• Viral Oncogenesis

Unifying the Concepts

• Cooperation of Multiple Biological Processes is Needed for the Development of Fully Fledged Malignancy
• Carcinogenesis In Vivo: Animal Models and Basic Approaches to Generate Genetically Modified Animals
• Multistage Carcinogenesis in Humans: Molecular Epidemiology and the Colon Cancer Model

Index

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