Understanding Nicotine and Tobacco Addiction deals with the problems involved in understanding and treating nicotine and tobacco addiction.

Features:

• Includes the nature of the worldwide health problem posed by cigarette smoking, the psychodynamics of cigarette addiction, and the basic pharmacology and biochemistry of nicotine and its effect on the brain
• Analyses the genetic basis of susceptibility to nicotine addiction
• Addresses approaches to therapy

Contents

1. The hazards of smoking and the benefits of stopping
2. Animal models for nicotine dependence
3. Defining and assessing nicotine dependence in humans
4. Nicotinic acetylcholine receptor functions in the CNS investigated with a novel method of stereotaxic gene re-expression in knockout mice
5. Nicotine-mediated activation of signal transduction pathways
6. Complementary roles for the accumbal shell and core in nicotine dependence
7. The dopamine D3 system: new opportunities for dopamine-based reward
8. Pathways and systems involved in nicotine dependence
9. Localizing tobacco dependence pathways with functional brain imaging
10. Pharmacogenetic approach to nicotine dependence treatment
11. Pharmacogenomics and smoking cessation
12. General discussion II Power in studies
13. Receptor desensitization
14. What limits the efficacy of current nicotine replacement therapies
15. Exploring behavioural mechanisms of nicotine replacement therapy for smoking cessation
16. Modifying the metabolism of nicotine as a therapeutic strategy
17. Challenges in discovery and development of pharmacotherapies for tobacco addiction
18. Final discussion Nicotine comorbidity

Index

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