Understanding Drug Release and Absorption Mechanisms builds a firm understanding of all elements needed to conceive, build, and implement successful models of drug release. It discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results.

Features:

• Presents methods for building simple yet reliable models of drug release for a variety of drug delivery systems
• Discusses the underlying physiological, mathematical, and physical concepts on which the models are based
• Covers oil-water partitioning and drug dissolution as well as the anatomy, physiology, and mechanisms of drug release
• Considers the theoretical and experimental aspects of drug solubility dependence on drug crystal size
• Demonstrates the application of several models to various systems and compares the output to experimental results

Contents

Mathematical Modeling

• Model Building
• Model Fitting
• Models Comparison

Gastrointestinal Tract

• Macro- and Microscopic Anatomy of the Gastrointestinal Tract
• Intestinal Absorption
• Human and Animal GI Tract: A Comparison

Skin

• Anatomy
• Skin Delivery Strategies
• Animal Model of Skin Delivery

Rheology

• Viscosity and Newtonian Fluids
• Shear-Dependent Viscosity and Non-Newtonian Fluids
• Shear Flows
• Not Only Viscosity: Normal Stress Differences and Other Material Functions
• Extensional Flows and Complex Flows
• Time-Dependence: Thixotropy and Viscoelasticity
• Linear Viscoelasticity
• Rheological Properties and Structural Features
• Conclusive Considerations on Rheology Applications to Drug Delivery Systems

Mass Transport

• Thermodynamic Concepts
• Kinetics
• Fick's Equation
• Effect of Initial and Boundary Conditions

Drug Dissolution and Partitioning

• Dissolution
• Partitioning
• Dissolution and Partitioning

Dissolution of Carystallites: Effects of Size on Solubility

• Thermodynamic Concepts
• Experimental Methods and Limitations

Drug Release from Matrix Systems

• Matrices
• Mathematical Modeling

Drug Release from Microemulsions

• Microemulsions: Structure
• Microemulsions: Thermodynamics
• Microemulsions: Experimental Characterization
• Microemulsions and Drug Release

Drug Permeation Through Membranes

• Synthetic Membranes
• Biological Membranes

Index

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