edited by Alvin Berger
and Matthew A. Roberts

With contributions from renowned scientists and researchers in the field, Unravelling Lipid Metabolism with Microarrays

• rovides detailed guidance on procedures to handle omic data sets
• Contains an extensive overview of statistical approaches to evaluate microarray data
• Considers how microarrays can be used to understand the role of lipids in the initiation or prevention of disorders including cancer, diabetes, and obesity
• Includes a summary of experiments utilizing NMR for the examination of lipid transformations
• Studies the use of the zebra fish model for clarification of the whole body lipid metabolism

Unravelling Lipid Metabolism with Microarrays demonstrates the use of microarrays and transcriptomic approaches to clarify the biological function of lipids, reviewing current studies and previously unpublished research from leading laboratories around the world.

Unravelling Lipid Metabolism with Microarrays provides detailed guidance on procedures to handle omic data sets, an extensive overview of statistical approaches to microarray data, and discussions on how microarrays can be used to understand the role of lipids in the initiation or prevention of disorders such as cancer, diabetes, and obesity.

Of particular note is a chapter by the only group known to study the effect of lipids on transcriptomics in multiple brain regions.

Contents

• Statistical Design and Data Analysis for Microarray Experiments
• Dietary Effects of Arachidonate-Rich Fungal Oil and Fish Oil on Murine Hepatic Gene Expression: Focus on Newly Described LC-PUFA-Regulated Genes
• Dietary Effects of Arachidonate-Rich Fungal Oil and Fish Oil on Murine Hippocampal Gene Expression
• Exploring the Effects of Polyunsaturated Fatty Acids on Gene Expression in Human Hepatocyte Using DNA Chip
• Neurological Effects of Dietary n-3 Fatty Acids in Rat Brain
• Anterior and Posterior Cerebral Gene Expression in a Rat Model of Reduced Brain Docosahexaenoic Acid During Development
• A Genomic Approach to Studying Leptin Signaling in a Hypothalamic Cell Line
• Characterizing Cholesterol Metabolism in Atherosclerosis Susceptible and Resistant Mouse Models Using DNA Microarrays
• Microarray Analysis of Lipid Metabolism in Drug Abuse, Neurological and Psychiatric Disorders
• Microarray Analysis of SREBP-1 Target Genes

Index

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