Features:

• Demonstrates how to apply mass spectrometry in determining drug metabolism
• Provides explanation of different drug metabolism concepts and their importance
• Includes most up-to-date information on the latest equipment and techniques
• Provides applications and examples in most chapters

Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this exciting field. The author demonstrates how to apply MS to determine drug metabolism. It explains the different drug metabolism concepts and their importance.

This book gives drug researchers and pharmacokineticists the latest information available on this important technology.

Contents

1. Bioanalytical Assays in a Drug Discovery Environment
2. Drug Metabolism In-vitro and In-vivo Results: How Do These Data Support Drug Discovery
3. In-vitro Assays: How Fast Can We Go?
4. Matrix Effects: Causes and Solutions
5. Direct Plasma Analysis Systems and Applications
6. Acyl-Glucuronides - Assays and Issues
7. Utilizing Higher Mass Resolution in Quantitative Assays
8. Special Requirements for Metabolite Characterization
9. APPI: A New Ionization Source for LC-MS/MS Assays
10. Q-Trap: a New MS Tool for Metabolite Identification
11. MS Imaging New Technology Provides New Opportunities
12. Nano-Flow/Chip Technologies: Where Are These Going?

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ORDER NOW Using Mass Spectrometry for Analyzing Drug Metabolism by Walter Korfmacher 440 pages • $188.95 + shipping Texas residents please add 6.75 % sales tax