Vaccine Adjuvants and Delivery Systems brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants.

Vaccine Adjuvants and Delivery Systems:

• Provides a comprehensive overview of the rapidly evolving field and developing formulation methods
• Covers cutting-edge technologies and gives the current status of adjuvants in clinical trails and those still in the pre-clinical stage
• Includes detailed information on specific vaccine adjuvans, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more
• Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions
• Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants

Contents

1. Development of vaccine adjuvants - a historical perspective
2. Antigen-Processing and Presentation
3. Mechanisms of Adjuvant Action
4. Aluminum-containing Adjuvants: Properties, Formulation and Use
5. MF59: A Safe and Potent Oil in Water Emulsion Adjuvant
6. TLR4 agonists as vaccine adjuvants
7. Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants
8. Small Molecule Immunopotentiators as Vaccine Adjuvants
9. New ISCOMs Meet Unsettled Vaccine Demands
10. Surface Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems
11. Liposomal Cytokines and Liposomes Targeted to Costimulatory Molecules as Adjuvants for HIV Subunit Vaccines
12. Archaeosomes Vaccine Adjuvants for Cross-priming CD8+ T Cell Immunity
13. Mucosal Adjuvants and Delivery Systems
14. Cytokines as Vaccine Adjuvants
15. Polyphosphazenes as vaccine adjuvants
16. Vaccine Delivery by Transdermal Electroporation
17. Nonclinical Safety Assessment of Vaccines, and the Evaluation of Novel Adjuvants and Delivery Systems
18. Safety Evaluation of Vaccine Adjuvants

Index

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