Crystal-Induced Arthropathies provides an in-depth review of crystal-induced arthritis and related disorders.

Features:

• Reviews clinical approaches to patients with crystal-induced arthritis, including information on pharmacologic interventions, complete with medications and dosing schedules
• Covers the pharmacology of the most commonly used drugs and reviews mechanisms of action, side effects, drug interactions, indications, and contraindications for colchicine, nonsteroidal anti-inflammatory drugs, corticosteroids, xanthine oxidase inhibitors (including the newest one, febuxostat), and uricosuric agents
• Analyzes potential new therapies such as parenteral uricase for the treatment of select individuals with gout and strategies to counteract the biologic effects of calcium containing crystals
• Examines rare presentations of disease such as early onset gout, gout in women, and gout in organ transplant patients, as well as associated conditions such as cardiovascular and metabolic disorders
• summarizes classic radiographic research on the various forms of crystal-induced arthropathy and includes 26 radiographs that demonstrate these findings
• Considers methods of crystal identification such as electron microscopy, atomic force microscopy, and Fourier transform infrared spectroscopy, and considers the applicability, cost, performance, sensitivity, and advantages of each technique

Contents

• Crystal Induced Arthropathies
• Epidemiology of Crystal-Induced Arthropathy
• Genetics of Crystal-Induced Arthropathies
• Clinical Features of Gout
• Asymptomatic Hyperuricemia
• Clinical Features of Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
• Clinical Features of Basic Calcium Phosphate-Associated Syndromes
• Differential Diagnosis of Acute Monarthritis
• Synovial Fluid Analysis for Identification of Crystals
• Other Methods of Crystal Identification
• Radiographic Changes of Crystal-induced Arthropathies
• Biochemistry of Hyperuricemia and Gout
• Biochemistry of Calcium Pyrophosphate Crystal Deposition
• Biochemistry of Basic Calcium Phosphate Associated Syndromes
• Pathophysiology of Crystal-Induced Arthritis
• Urate Physiology
• Pathophysiology and Biologic Effects of Crystals
• Pathology of Crystal-Induced Arthritic Syndromes
• Management of the Crystal-Induced Arthritic Syndromes
• Colchicine
• Nonsteroidal Anti-inflammatory Drugs
• Corticosteroids
• Uricosuric Agents
• Xanthine Oxidase Inhibitors
• Uricase
• Therapeutic Agents for Calcium Crystal Arthropathies

Index

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