Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis offers guidelines to currently available technology and bioinformatics and database strategies now being developed.

Evidence is presented that metabolic profiling is a valuable addition to genomics and proteomics strategies devoted to drug discovery and development, and that metabolic profiling offers numerous advantages.

Contents

1. Introduction
2. Metabolome and Proteome Profiling for Microbial Characterization
3. Can ¹H NMR Derived Metabolic Profiles Contribute to Proteomic Analyses?
4. Application of Metabonomics in the Pharmaceutical Industry
5. Metabolic Profiling in Tumors by In Vivo and In Vitro NMR Spectroscopy
6. Raman Spectroscopy for Whole Organism and Tissue Profiling
7. Metabolic Fingerprinting with Fourier Transform Infrared Spectroscopy
8. Metabolomic analysis with Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
9. Stable Isotope-Based Dynamic Metabolic Profiling in Disease and Health
10. The Role of Metabolomics in Systems Biology
11. Use of Metabolomics to Discover Metabolic Patterns Associated with Human Diseases
12. Bioactive Lipids in Reproductive Diseases
13. Evolutionary Computation for the Interpretation of Metabolomic Data
14. Dynamic Profiling and Canonical Modeling
15. Databases, Data Modeling and Schemas
16. Databases and Visualization for Metabolomics
17. The Human Metabolome

Index

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