Peptidomics describes the methods of peptidomics for the study of proteins, how it works, and applications in areas from drug discovery to toxicity biomarker analysis.

The book provides information that is both sufficiently detailed to be a step-by-step guide for beginning researchers, while also being a reference for experienced professionals.

Peptidomics explains the current state of the field, new developments now emerging, and examples of applications for in fields from pharmaceutical science, to toxicity biomarkers, to neuroscience.

Contents

Studies of Naturally Occurring Peptides

1. Analysis of the peptidomes of amphibian skin granular gland secretions - an integrated functional genomic strategy
2. A short history of insect (neuro)peptidomics - A personal story of the birth and youth of an excellent model for studying peptidome biology
3. Peptidomics of short linear cytolytic peptides from spider venom
4. Molecular cloning approaches to peptidomics: the identification of novel cDNAs encoding neurotoxin-like peptide pools
5. Wheat antimicrobial peptides
6. Immunopeptidomics: Applications to dissect immune responses through proteomic-based approaches
7. Strategies for reliable and improved identification of peptides

Peptidomics Methods and New Developments

8. Peptidomics approach to proteomics
9. The importance of sample handling in neuropeptidomics
10. Affinity peptidomics and protein microarrays: application to forensics and biometrics
11. Selective depletion and enrichment methods for the analysis of protein and peptide pools
12. Detection of target peptides in foods and feeds by mass spectrometry
13. Quantification of Polypeptides by Mass Spectrometry

Peptidomics Approach to Biomarker Discovery

14. Biomarker discovery
15. Can peptidomics provide a useful approach for the identification of biomarkers of toxicological exposure or effect
16. Peptidomics in Neuroendocrine research: a Caenorhabditis elegans and Mus musculus study

Conclusion

17. Peptidomics and Biology: two scientific disciplines driving each other

Index

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