Entirely updating and expanding the First Edition of these well-received references, Disperse Systems • Volume 1 offers new data on:

• Light scattering techniques and improvements in microscopy
• An enlarged description of emulsification
• Novel applications of colloids and pseudolatex polymer dispersions
• New discussions on micellar shape and the concept of the critical packing parameter
• Updates analyses of regulatory and compendial concepts of drug products and their safety
• A rewritten and expanded section on bioavailability of disperse dosage forms
• And more!

Contains hundreds of bibliographic citations, tables, drawings, photographs, and equations.

Contents

1. Introduction
   Free Energy Considerations
   Stabillity Considerations
   Protocols

2. Theory of Suspensions
   Classification of Dispersed Systems
   Particle Properties
   The Solid-Liquid Interface
   Preparation
   Stabilization
   Rheological Aspects
   Effect of Additives

3. Theory of Emulsions
   General Aspects of Emulsions
   Stability of Two-Phase Emulsions
   Stability of Three-Phase Emulsions

4. Theory of Colloids
   Electrostatic stabilization of Latexes
   Steric Stabilization of Latexes
   Preparation of Latexes by Direct Emulsification

5. Rheological and Mechanical Properties of Dispersed Systems
   Fundamentals
   Elasticity and Viscosity
   Viscometry
   Rheology of Dispersed Systems

6. Surfactants
   Definitions and General Proerties of Surfactants
   Physical Description of Surfactants in Solution
   Chemical Description of Surfactants
   Special Topics
   Biological Effects of Surfactants
   Use of Surfactants in Drug Products
   Effect of Surfactants on Drug Efficacy

7. Viscosity-Imparting Agents in Disperse Systems
   Polymer Solution Rheology
   Sedimentation Control in Disperse Systems
   Viscosity Changes During Product Aging
   Flocculation and Deflocculation Phenomena
   Excipient Compatability
   Polymer Selection
   Viscosity-Building Substances
   Sample Formulations

8. Bioavailability of Disperse Dosage Forms
   Formulation Factors Affecting Drug Release from Disperse Systems
   Principles of Drug Release from Disperse Systems
   In Vitro-In Vivo Correlations
   Physiological Factors Affecting Bioavailability
   Methods of Assessing Drug Bioavailability
   In Vivo Bioavailability Assessment

9. Preservation of Dispersed Systems
   General Characteristics
   Microbial Contamination
   Preservatives
   Effects of Product Ingredients on Preservative Activity
   Evaluation of Preservative Efficacy
   Future Trends

10. Experimental Design, Modeling, and Optimization Strategies for Product and Process Development
    Deterministic Modeling
    Stochastic Modeling

Index

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