Pharmaceutical Extrusion Technology details

• extruder hardware and controls
• screw and die designs
• process definition and troubleshooting of single- and twin-screw extrusion processes
• the application of extrusion technology in pharmaceutical dosage form development
• qualification and validation of extruders and extrusion processes

In-depth descriptions and analyses of the key parameters of extruders and extrusion processes - highlighting the applicability of melt extrusion in pharmaceutical drug development and manufacturing, including controlled release, dissolution rate and bioavailability enhancement, and granulation technology are provided. All the technical information necessary to develop and market pharmaceutical dosage forms that meet the current quality and regulatory requirements are brought together here.

Contents

1. Historical Overview
2. Extruder Design
3. Single-Screw Extrusion and Screw Design
4. Twin-Screw Extrusion and Screw Design
5. Die Design
6. Material Handling and Feeder Technology
7. Rheology and Torque Rheometers
8. Process Design
9. Melt Pelletization
10. Melt-Extruded Controlled-Release Dosage Forms
11. Shape Extrusion
12. Film, Sheet, and Laminates
13. Melt-Extruded Molecular Dispersions
14. Extrusion/Spheronization
15. Twin-Screw Wet Granulation
16. Installation, Commissioning, and Qualification
17. Controls and Instrumentation
18. Future Trends

Index

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