Therapeutic Aspects of Biomacromolecules by Christine M. Bladon
Illustrated with numerous examples, Pharmaceutical Chemistry covers essential compounds and explains how they exert their influence through an understanding of biological processes.
Key strategies involved in the development and production of a range of clinically useful compounds are presented along with a broad overview of the way in which peptides, proteins, nucleic acids and carbohydrates are used therapeutically.
Key Features:
- a comprehensive introduction to this evolving field
- numerous examples and problems focusing on fundamental concepts and ideas to enhance understanding
- coverage of various strategies behind the development and production of a range of key clinically useful compounds
Contents:
- Introduction
- Overview
- Biomacromolecules in the Treatment of Human Disease
- Endogenous Peptides and Proteins
- Overview
- Isolation from Natural Tissues and Fluids
- Synthesis and Semi-Synthesis
- Gene Cloning
- Transgenic Procedures
- Examples of Direct Replacement Strategy
- Modification of Endogenous Peptides and Proteins
- Overview
- Peptide Mimetics
- Chemical Modification of Proteins
- Protein Engineering
- The Immune System
- Overview
- The Antibody-Mediated Response
- Vaccines
- The Cell-Mediated Immune Response
- Cancer Immunotherapy
- Oligonucleotides
- Overview
- Gene Therapy
- Antisense Therapy
- Ribozymes
- Oligosaccharides
- Overview
- Oligosaccharide Synthesis
- Heparin
- Glycoproteins
- Polysaccharide Bacterial Vaccines
- Approaches to Carbohydrate-Based Cancer Vaccines
Appendix
Glossary
Index
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