Polymorphism in the Pharmaceutical Industry fills a need by emphasizing exactly why solid-state issues are important.

Features:

• Demonstrates which approaches should be taken to avoid problems and to exploit the opportunities offered by solid-state properties in the pharmaceutical, agricultural and fine chemical industries
• Describes a guideline for development chemists just entering this rapidly expanding field
• Is a reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments

Contents

1. Relevance of Solid-state Properties for Pharmaceutical Products
2. Thermodynamics of Polymorphs
3. Characterization of Polymorphic Systems using Thermal Analysis
4. Solid-state NMR Spectroscopy
5. Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization
6. Crystallography for Polymorphs
7. Light Microscopy
8. The Importance of Solvates
9. Physical Characterization of Hygroscopicity in Pharmaceutical Solids
10. The Amorphous State
11. Approaches to Polymorphism Screening
12. Salt Selection
13. Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality
14. Polymorphism and Patents from A Chemist?s Point of View
15. Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications

Index

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