Practical Aspects of Hyaluronan Based Medical Products in detail the chemistry, composition, formulation, testing, safety, effectiveness, quality control, and regulatory approval of HA medical products.

Features:

• Provides the first systematic treatment of the practical aspects of hyaluronan products, not just the research
• Supplies more than 50 figures of chemical structures, reaction schemes, and rheological properties
• Surveys the clinical information on safety and performance and uses it to evaluate product design rationale
• Explains the basic rheological concepts of HA and emphasizes the practical aspects without complicated mathematical formulas
• Summarizes the related standards, commonly used test methods, and quality control considerations of HA products

Contents

Overview

• Discovery
• Primary Structure
• Molecular Formula
• Member of Glycosaminoglycans
• HA Structures of Higher Orders
• Viscosity, Molecular Weight, and Structures
• Source and Isolation
• Distribution and Catabolism
• Influence on Cell Behavior
• Chemical Modification
• HA-Based Medical Products
• Ever-Growing Interest

Chemistry

• Chemistry in Structural Investigation
• Chromogenic Reactions
• Chemistry of HA Degradation
• Chemistry in Isotopic Labeling
• Synthesis of Fluorescent HA
• Biotinylated HA
• HA Derivatives with Various Side Chains
• HA-Drug Conjugation
• Chemical Crosslinking of HA
• Preparation of Oligosaccharides
• Sulfation of HA
• Summary of Methods of Chemical Modification

Rheological Properties of Hyaluronan as Related To Its Structure, Size, and Concentration

• Some Basic Concepts of Intrinsic Viscosity
• Hydrodynamic Volume and Molecular Structures
• Absolute Viscosity Measured at Steady State
• Viscoelasticity

Standards, Tests, and Analytical Metholds

• Standards and Specifications
• Analyses of HA Structure, Size, and Quantity
• Natural Polymeric Impurities
• Other Bioassays
• Lipoteichoic Acid
• Chemical Methods of Radiolabeling

Safety of Hyaluronan-Based Medical Products In Their Intended Applications

• General Safety Considerations
• Safety Information from Specific Human Use

Clinical Performance, Mechanism of Action, and Product Chararteristics

• Ophthalmic Surgeries
• Injections for Osteoarthritic Knees
• Adhesion Prevention and Wound Healing
• Tissue Augmentation
• Dental and Bone Application

Index

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